• One Health
  • Pain Management
  • Oncology
  • Anesthesia
  • Geriatric & Palliative Medicine
  • Ophthalmology
  • Anatomic Pathology
  • Poultry Medicine
  • Infectious Diseases
  • Dermatology
  • Theriogenology
  • Nutrition
  • Animal Welfare
  • Radiology
  • Internal Medicine
  • Small Ruminant
  • Cardiology
  • Dentistry
  • Feline Medicine
  • Soft Tissue Surgery
  • Urology/Nephrology
  • Avian & Exotic
  • Preventive Medicine
  • Anesthesiology & Pain Management
  • Integrative & Holistic Medicine
  • Food Animals
  • Behavior
  • Zoo Medicine
  • Toxicology
  • Orthopedics
  • Emergency & Critical Care
  • Equine Medicine
  • Pharmacology
  • Pediatrics
  • Respiratory Medicine
  • Shelter Medicine
  • Parasitology
  • Clinical Pathology
  • Virtual Care
  • Rehabilitation
  • Epidemiology
  • Fish Medicine
  • Diabetes
  • Livestock
  • Endocrinology

Journal Scan: Bigger dogs may need less trilostane to control hyperadrenocorticism

Article

New research shows sensitivity to trilostane may increase as body weight increases.

What they did

In a retrospective study, researchers evaluated 70 dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH) being treated with trilostane.

What they found

Dogs weighing > 66 lb (30 kg) required less trilostane to control their clinical signs. The results did not achieve statistical significance, but a trend suggested that as body weight increased, the relative amount of trilostane needed to control signs decreased. The researchers also found that only 11% of dogs required more than 3 mg/kg/dose to control their disease-the manufacturer's recommended initial dose is 3 to 6 mg/kg once daily.

Take-home message

Sensitivity to trilostane may increase as body weight increases, so larger dogs with PDH may require lower relative doses of trilostane. Additionally, study data suggest that the initial dosage recommendation of 3 to 6 mg/kg/day be reconsidered.

Feldman EC, Kass PH. Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med 2012;26(4):1078-1080.

Link to abstract: http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2012.00956.x/abstract

Related Videos
dvm360 Live! with Dr. Adam Christman
dvm360 Live! with Dr. Adam Christman
dvm360 Live! with Dr. Adam Christman
© 2024 MJH Life Sciences

All rights reserved.