Practical Matters: Prudent NSAID use helps prevent adverse effects
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but, in rare cases, can cause serious side effects including gastrointestinal ulceration, renal failure, platelet dysfunction, and hepatotoxicosis. Newer-generation NSAIDs approved for use in dogs and cats are selective or preferential cyclooxygenase or cyclooxygenase and lipoxygenase inhibitors. They have a reported risk of side effects that are generally dose-related. However, adverse effects may be unpredictable. Clinical experience has demonstrated that a single dose of an NSAID in a stable cat undergoing anesthesia for an ovariohysterectomy can result in renal failure.
Editors’ note: For a client handout on using NSAIDs safely in pets, go to http://www.fda.gov/cvm/Documents/NSAIDBrochure.pdfREFERENCES
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Elke Rudloff, DVM, DACVECC