Often referred to as sago palms, cycads are hardy evergreen yard plants that grow in warm states, such as Florida, North Carolina, and Georgia, and are also used as ornamental houseplants.1 Lately, their increased use as houseplants has made them available all over the world.2 Cycads, such as Zamia floridana, Cycas revoluta, and Cycas circinalis, arose from vegetation that dominated in the Mesozoic era.
Cycad toxicosis has been described in people and many animals, including dogs, sheep, and cattle. In this article, I focus on the clinical signs, diagnosis, and treatment of cycad toxicosis in dogs.
TOXICITY AND MECHANISM OF ACTION
Cycad palms produce three toxins: cycasin, beta-methylamino-L-alanine, and an unidentified toxin.3-6
Cycasin, which is converted to its aglycone, methylazoxymethanol, may cause centrilobular and midzonal coagulative hepatic necrosis and gastrointestinal irritation. In addition, cycasin is carcinogenic, mutagenic, and teratogenic.3,5,6
Beta-methylamino-L-alanine, a neurotoxic amino acid, causes ataxia in rats and is implicated in Guam disease in people. Guam disease is characterized by symptoms similar to those of Alzheimer, Parkinson, and Lou Gehrig (amyotrophic lateral sclerosis) diseases.3,5,6
The unidentified toxin, a high-molecular-weight compound, may cause hindlimb paralysis in cattle because of axonal degeneration in the central nervous system.3,5,6
All parts of the plant are toxic, but the seeds contain higher amounts of cycasin than do other parts of the plant. Dogs usually ingest the seeds. Although toxic, the young leaves are palatable.7-9
In one study, the most common signs in dogs ingesting cycad plants were gastrointestinal, hepatic, and neurologic.10 In cases reported to the American Society for the Prevention of Cruelty to Animals (ASPCA) Animal Poison Control Center and recorded in the AnTox database between 1988 and 1998, the most common signs of cycad toxicosis in dogs were vomiting (with or without blood), depression, diarrhea (with or without blood), and anorexia.11 AnTox data from 2000 through 2007 show the same common signs of cycad toxicosis in dogs as mentioned above.
Gastrointestinal signs may develop within 24 hours, but bilirubin concentrations and serum alanine aminotransferase and alkaline phosphatase activities may not become elevated for 24 to 48 hours.10 Signs may last from 24 hours to nine days.11
Gastrointestinal abnormalities in dogs with cycad poisoning include hemorrhage and mucosal necrosis. Histologic abnormalities in the livers of these dogs include cirrhosis with marked focal centrilobular and midzonal coagulation necrosis.2
Cycad toxicosis is diagnosed based on a history of known exposure (e.g. observed ingestion, identification of chewed plants, identification of plant material in vomitus) and compatible clinical signs. Although cycasin and beta-methylamino-L-alanine can be found in the livers of animals that ingest cycad palms, no diagnostic laboratories routinely test for these compounds.2
TREATMENT AND MONITORING
Treatment of cycad toxicosis is symptomatic and supportive. No antidote for any cycad toxin is available.2 Measure hepatic enzyme activities and bilirubin concentrations on presentation, and monitor these values daily for 72 hours. If elevations are found, monitor the parameters until they return to normal. Administer supportive therapy as needed.
Perform gastric lavage or induce emesis by using hydrogen peroxide (1 ml/lb; maximum = 45 ml) in asymptomatic dogs as soon as possible after suspected ingestion. Repeated doses of activated charcoal at 1 to 2 g/kg may be given after emesis.
If clinical signs are present, supportive therapy is indicated. For gastrointestinal signs, administer sucralfate (1 g in large dogs or 0.5 g in small dogs orally every eight hours) and cimetidine (5 to 10 mg/kg intravenously or orally every eight hours if the dog is not vomiting) or other gastric acid inhibitors.12 Supportive fluid therapy with 5% dextrose in 0.9% saline solution is recommended, and blood glucose concentrations should be closely monitored.13 Seizures and tremors may be controlled with diazepam (2 to 5 mg/kg intravenously in dogs, as needed).12 If gastrointestinal tract hemorrhage is severe, blood transfusions may be necessary.
Monitor dogs for secondary effects of liver failure, such as coagulopathy, hepatic encephalopathy, hypoproteinemia, or renal failure, and treat these conditions as needed.10 A low-protein bland diet is recommended. S-adenosyl-methionine (17 to 20 mg/kg daily in dogs) has been recommended in the long-term management of hepatic injury.12
A patient's prognosis is good if treatment is instituted soon after cycad ingestion. However, if the patient is showing clinical signs, its prognosis is guarded.2 The reported mortality rate in dogs with clinical signs is 32.1%.11
"Toxicology Brief" was contributed by Hany Youssef, BVSc, DVM, MS, ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, IL 61802. The department editor is Petra Volmer, DVM, MS, DABVT, DABT.
1. North Carolina Cooperative Extension Service, North Carolina State University. Poisonous plants of North Carolina. Available at: www.ces.ncsu.edu/depts/hort/consumer/poison/poison.htm . Accessed Mar 31, 2008.
2. Albretsen J. Cycasin. In: Plumlee KH. Clinical veterinary toxicology. St. Louis, Mo: Mosby, 2004;392-394.
3. Cheeke PR. Natural toxicants in feeds, forages, and poisonous plants. Danville, Ill: Interstate Publishers, 1998;388-389.
4. Hooper PT. Cycad poisoning in Australia—etiology and pathology. In: Keeler RF, Van Kampen KR, James LF, eds. Effects of poisonous plants on livestock. New York, N.Y.: Academic Press, 1978;337-347.
5. Kinghorn D. Carcinogenic and cocarcinogenic toxins from plants. In: Keeler RF, Tu AT, eds. Handbook of natural toxins: plant and fungal toxins Vol 1. New York, N.Y.: Marcel Dekker, 1983:239-298.
6. Senior DF, Sundloff SF, Buergelt CD, et al. Cycad intoxication in the dog. J Am Anim Hosp Assoc 1985;21:103-109.
7. Botha CJ, Naude TW, Swan GE, et al. Suspected cycad (Cycas revoluta) intoxication in dogs. J S Afr Vet Assoc 1991;62(4):189-190.
8. Knight MW, Dorman DC. Selected poisonous plant concerns small animals. Vet Med 1997;92(3):260-272.
9. Reams RY, Janovitz EB, Robinson FR, et al. Cycad (Zamia puertoriquensis) toxicosis in a group of dairy heifers in Puerto Rico. J Vet Diagn Invest 1993;5(3):488-494.
10. Albretsen JC, Khan SA, Richardson JA. Cycad palm toxicosis in dogs: 60 cases (1987-1997). J Am Vet Med Assoc 1998;213(1):99-101.
11. AnTox Database. Urbana, Ill: ASPCA Animal Poison Control Center, 1988-1998.
12. Plumb DC. Veterinary drug handbook. 5th ed. Ames: Iowa State University Press, 2005;245-248, 340-345, 995-997, 1038-1039.
13. Leveille-Webster CR. Diseases of the hepatobiliary system. In: Morgan RV, ed. Handbook of small animal practice. 3rd ed. Philadelphia, Pa: WB Saunders Co, 1997;383-401.