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I am treating a 5-year-old Great Dane that has anal sacculitis. Standard treatment consisting of cephalexin; an antibacterial,
anti-inflammatory, and antifungal ointment; and a tapering dosage of hydrocortisone has been unsuccessful. I'm trying to avoid
surgery. Any ideas?
A. Before increasing your systemic therapy dosages or performing more frequent local treatments, you should ensure that the
anal sacs are the real problem. Anal pruritus unrelated to anal sacs can mimic the clinical signs of anal sacculitis, but
the two are distinguishable. If anal sacculitis is truly the problem, the pruritus should resolve after the anal sacs are
Dr. Paul Bloom
Conflicting reports exist regarding the value of gross and cytologic examination of anal sac exudates in diagnosing anal sacculitis.
This is because of the extreme heterogenicity in color, consistency, amount of solid material, inflammatory cells, bacteria,
yeast and RBCs contained in the expressed secretions from both normal1 and affected dogs. Some reports correlated anal sacculitis with the presence of large numbers of nondegenerative neutrophils
and intracellular bacteria.2,3 However, in the most recent study,4 there were dogs with anal sac disease that had minimal to no inflammation nor bacteria present on cytology, and there were
normal dogs with large numbers of inflammatory cells and bacteria present on cytology.4 Thus the numbers of inflammatory cells and bacteria are not statistically different between normal dogs and dogs with anal
Anal sacculitis may be associated with allergies, perianal fistulas, and gastrointestinal disease, particularly if the stools
are not well-formed. It may also be idiopathic.
Recommended initial treatment protocols include frequent manual expression of the anal sacs, an increase in dietary fiber,
locally infused combination antibiotic and corticosteroid products, and systemic use of corticosteroids. For grossly infected
anal sacs, systemic antimicrobials may be initiated but are rarely effective.
For refractory cases, anal sacculectomy is frequently the best treatment option.
Paul Bloom, DVM, DACVD, DABVP
Allergy, Skin and Ear Clinic for Pets
31205 Five Mile
Livonia, MI 48154
1. Lake AM, Scott DW, Miller WH Jr, et al. Gross and cytological characteristics of normal canine anal-sac secretions. J Vet Med A Physiol Pathol Clin Med 2004;51(5):249-253.
2. Robson DC, Burton GG, Lorimer MF. Cytological examination and physical characteristics of the anal sacs in 17 clinically
normal dogs. Aust Vet J 2003;81(1-2):36-41.
3. Pappalardo E, Martino PA, Noli C. Macroscopic, cytological and bacteriological evaluation of anal sac content in normal dogs
and in dogs with selected dermatological diseases. Vet Dermatol 2002;13(6):315-322.
4. James DJ, Griffin CE, Polissar NL, Neradilek MB. Comparison of anal sac cytological findings and behaviour in clinically
normal dogs and those affected with anal sac disease. Vet Dermatol 2011;22(1):80-87.