A 12-year-old 74-lb (33.7-kg) spayed female Labrador retriever was presented to the Colorado State University James L. Voss
Veterinary Teaching Hospital for evaluation of a superficial corneal ulcer of the right eye of three weeks' duration. Despite
medical therapy by the referring veterinarian, consisting of topical antibiotics of unknown type, atropine, and autogenous
serum, the eye had not improved.
The dog had been healthy all its life and had never received any medical treatments. It was current on its vaccinations and
heartworm preventive. No blood work or urinalysis had been done within the prior year.
A complete ophthalmic examination revealed a raised, pink mass (measuring 4 mm x 7 mm) of granulation-like tissue on the right
corneal surface and moderate iris atrophy and nuclear sclerosis in both eyes. Mild conjunctival hyperemia was present in the
right eye, and small, superficial corneal blood vessels extended from the lateral limbus to the centrally located mass. The
pink mass was adjacent to a corneal area that appeared ulcerated. Fluorescein staining of the cornea confirmed that this area
was a superficial corneal ulcer. The results of Schirmer tear tests and tonometry were normal in both eyes. The results of
the remainder of the ophthalmic and physical examinations were normal.
We diagnosed a spontaneous chronic corneal epithelial defect (SCCED) in the right eye with secondary granulation tissue formation.
The SCCED diagnosis was based on the fact that the ulcer was superficial and undermined (had a surrounding lip of epithelium
that was not attached to the anterior corneal stroma) and was not healing. In addition, we had ruled out other causes of nonhealing
ulcers, such as keratoconjunctivitis sicca, persistent foreign bodies, infection, and eyelid anomalies such as distichiasis,
ectopic cilia, and entropion.1,2
Treatment for the ulcer consisted of applying a topical anesthetic and aggressive removal of the undermined corneal epithelium.
This was done by first rubbing off the tissue with a sterile, cotton-tipped applicator followed by superficial débridement
of the anterior stroma with a 3.5-mm, low-torque, diamond-tipped, motorized burr.3,4
The dog was discharged with instructions for the owner to administer topical 1% morphine ophthalmic drops (compounded by the
veterinary teaching hospital's pharmacy) three times a day in the right eye.5 The morphine was used to decrease the pain that is often present after débridement. A neomycin-polymyxin-gramicidin ophthalmic
ointment was also prescribed four times a day in the right eye for infection prophylaxis.
Two weeks later, the right cornea no longer retained fluorescein stain; however, a partially transparent scar remained in
the dorsotemporal quadrant. Antibiotics were discontinued, and the defect was considered healed.