We use a fair amount of maropitant (Cerenia—Pfizer Animal Health) in our practice. While it is useful, it seems to sting the
patient immediately after injecting it subcutaneously, especially the greater volumes required for large dogs. However, we
have noticed that refrigerating the medicine seems to almost eliminate the discomfort. While I still warn owners that the
injection might sting, they are almost always pleased to see that their pets aren't bothered by the injection.
Dr. John S. Parker