Examining the pathogenesis of feline hyperthyroidism - Veterinary Medicine
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Examining the pathogenesis of feline hyperthyroidism
Here's what is known about the development of this endocrinopathy and a look at areas researchers are probing. Additional knowledge from studies such as these will allow us to improve therapies and someday prevent this disorder.



1. Martin, K.M. et al.: Evaluation of dietary and environmental risk factors for hyperthyroidism in cats. JAVMA 217 (6):853-856; 2000.

2. Kass, P.H. et al.: Evaluation of environmental, nutritional, and host factors in cats with hyperthyroidism. J. Vet. Intern. Med. 13 (4):323-329; 1999.

3. Edinboro, C.H. et al.: Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats. JAVMA 224 (6):879-886; 2004.

4. White, H.L. et al.: Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats. AJVR 65 (5):586-591; 2004.

5. Hammer, K.B. et al.: Altered expression of G proteins in thyroid gland adenomas obtained from hyperthyroid cats. AJVR 61 (8):874-879; 2000.

6. Merryman, J.I. et al.: Overexpression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: An immunohistochemical analysis of 34 cases. Vet. Pathol. 36 (2):117-124; 1999.

7. Pearce, S.H. et al.: Mutational analysis of the thyrotropin receptor gene in sporadic and familial feline thyrotoxicosis. Thyroid 7 (6):923-927; 1997.

8. Peeters, M.E. et al.: Feline thyroid adenomas are in part associated with mutations in the G(s alpha) gene and not with polymorphisms found in the thyrotropin receptor. Thyroid 12 (7):571-575; 2002.


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