The efficacy of an acidified sodium chlorite solution to treat canine Pseudomonas aeruginosa otitis externa - Veterinary Medicine
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The efficacy of an acidified sodium chlorite solution to treat canine Pseudomonas aeruginosa otitis externa
These investigators evaluated an antimicrobial solution for use as an ear cleanser in dogs. All dogs had been treated unsuccessfully with other therapies before entering the study.


VETERINARY MEDICINE


Alternative treatments or control groups were not used in this study. There are several reasons for this study design. Because of the nature of the condition, a crossover study is impractical because the use of appropriate treatment may result in clinical resolution.6 Untreated controls were not used because spontaneous cure was unlikely in patients that had been unsuccessfully treated with topical or systemic therapies for at least six weeks before enrollment in the study. Additionally, Pseudomonas species are a perpetuating factor of otitis capable of maintaining an inflammatory response,6 and all patients had to be treated for humanitarian reasons. We did not determine whether twice-a-day flushing for 14 days with another product would produce similar results, although a single flush with saline solution before the Sanova treatment did not significantly alter culture counts. This suggests that the significantly reduced culture counts are not due to dilution alone.

Underlying causes of ear disease were not addressed in this study because of the study's short evaluation period. We recognize that successful management of ear disease requires diagnosis and treatment of primary and perpetuating factors.

Additional studies are needed to determine whether a more frequent treatment interval or a prolonged treatment period would result in a higher percentage of cures, as evidenced by clinical signs and bacterial cultures. Direct comparisons to products containing appropriate antibiotics (identified by bacterial culture and antimicrobial sensitivity testing) may help in determining the most efficacious treatment protocol. Additionally, Sanova may be more effective when used in conjunction with antibiotics. Developing a commercially available susceptibility test for Sanova would help to determine its proper place in the treatment of individual cases. However, the results of this study demonstrate that this cleanser is generally helpful in treating uncomplicated otitis externa caused by P. aeruginosa and may be especially appropriate when sensitivity data show that other antimicrobial therapy is unavailable or impractical.

Editor's note: This study was presented orally at the American Academy of Veterinary Dermatology and the American College of Veterinary Dermatology Annual Meeting in Kansas City, Mo., in April 2004. The abstracts from this meeting have been published in Vet Dermatol 2004;15(3):199-206.

ACKNOWLEDGMENTS

The authors acknowledge Alcide Corporation of Redmond, Wash., for its material support in the form of providing Sanova for this study. They also thank Chandra Cristofono, CVT, for her technical assistance.

Tim B. Strauss, DVM, DACVD
Tricia M. McKeever, MS, PhD*
Midwest Veterinary Dermatology
11850 Aberdeen St. NE
Blaine, MN 55449

Patrick J. McKeever, MS, DVM, DACVD
McKeever Dermatology Clinics
7723 Flying Cloud Drive
Eden Prairie, MN 55344

*Current address: Division of Respiratory Medicine, University of Nottingham, University Park, Nottingham, UK NG7 2RD

REFERENCES

1. Griffin CE. Otitis externa and otitis media. In: Griffin CE, Kwochka KW, MacDonald JM, eds. Current veterinary dermatology. Philadelphia, Pa: Mosby-Year Book, 1993;245-262.

2. Logas DB. Diseases of the ear canal. Vet Clin North Am Small Anim Pract 1994;24:905-919.

3. Dickson DB, Lore DN. Bacteriology of the horizontal ear canal of dogs. J Small Anim Pract 1983;24:413-421.

4. August JR. Otitis externa in the dog and cat, Part II: Pathogenesis of the disease, in Proceedings. West Vet Conf 1988;162-168.

5. Collaborative Microbiology Laboratories, Stony Brook, NY: Personal communication, 1994.

6. Kowalski JJ. The microbial environment of the ear canal in health and disease. Vet Clin North Am Small Anim Pract 1988;18:743-754.

7. Rosychuk RAW. Management of otitis externa. Vet Clin North Am Small Anim Pract 1994;24:921-952.


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Source: VETERINARY MEDICINE,
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