Answering your questions: Adult-onset neurodegenerative diseases in dogs and cats - Veterinary Medicine
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Answering your questions: Adult-onset neurodegenerative diseases in dogs and cats
Adult animals with progressive neurologic deficits merit a full diagnostic workup. Uncovering the cause leads to more informed treatment decisions and a more accurate prognosis.


25. Liu SK, Tilley LP, Tappe JP, et al. Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983). J Am Vet Med Assoc 1986;189:227-232.

26. Knowles K, Blauch B, Leipold H, et al. Reduction of spiral ganglion neurons in the aging canine with hearing loss. Zentralbl Veterinarmed A 1989;36:188-199.

27. Shimada A, Kuwamura M, Awakura T, et al. An immunohistochemical and ultrastructural study on age-related astrocytic gliosis in the central nervous system of dogs. J Vet Med Sci 1992;54:29-36.

28. Ferrer I, Pumarola M, Rivera R, et al. Primary central white matter degeneration in old dogs. Acta Neuropathol (Berl) 1993;86:172-175.

29. Summers BA, Cummings JF, De Lahunta A. The neuropathology of aging. In: Veterinary neuropathology. St. Louis, Mo: Mosby Inc, 1995;49-54.

30. Su MY, Head E, Brooks WM, et al. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging 1998;19:479-485.

31. Tapp PD, Siwak CT, Gao FQ, et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci 2004;24:8205-8213.

32. Head E, Torp R. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiol Dis 2002;9:1-10.

33. Cummings BJ, Satou T, Head E, et al. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: Evidence from cats and dogs. Neurobiol Aging 1996;17:653-659.

34. Nakamura S, Nakayama H, Kiatipattanasakul W, et al. Senile plaques in very aged cats. Acta Neuropathol (Berl) 1996;91:437-439.

35. Head E. Neurobiology of aging in dogs and cats, in Proceedings. 22nd Am Col Vet Intern Med Forum 2004;378-380.

36. Milgram NW, Zicker SC, Head E, et al. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging 2002;23:737-745.

37. Dodd CE, Zicker SC, Jewell CE, et al. Can a fortified diet affect the behavioral manifestations of age-related cognitive decline in dogs? Vet Med 2003;98;396-408.

38. Fechner H, Johnston PE, Sharp NJ, et al. Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German shepherd dogs with degenerative myelopathy. Berl Munch Tierarztl Wochenschr 2003;116:31-36.

39. Johnston PE, Knox K, Gettinby G, et al. Serum alpha-tocopherol concentrations in German shepherd dogs with chronic degenerative radiculomyelopathy. Vet Rec 2001;148:403-407.

40. Coates JR. Degenerative myelopathy, in Proceedings. 19th Am Col Vet Intern Med Forum, 2001;405-407.

41. Clemmons R. Degenerative myelopathy. In: Kirk RW, ed. Current veterinary therapy X small animal practice. Philadelphia, Pa: WB Saunders Co, 1989;830-833.

42. Clemmons RM. Degenerative myelopathy. Vet Clin North Am Small Anim Pract 1992;22:965-971.


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