The pathophysiology of DIC: When the hemostatic system malfunctions - Veterinary Medicine
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The pathophysiology of DIC: When the hemostatic system malfunctions
To diagnose disseminated intravascular coagulation and achieve the best outcome, you must first understand how the hemostatic system should work and what causes it to go awry in patients with this serious bleeding disorder.



1. Carr AP, Johnson GS. A review of hemostatic abnormalities in dogs and cats. J Am Anim Hosp Assoc 1994;30:475-482.

2. Couto CG. Disseminated intravascular coagulation in dogs and cats. Vet Med 1999;94:547-554.

3. Bateman SW, Matthews KA, Abrams AC. Disseminated intravascular coagulation in dogs: review of the literature. J Vet Emerg Critic Care 1998;8:29-45.

4. Bateman SW, Mathews KA, Abrams-Ogg AC, et al. Diagnosis of disseminated intravascular coagulation in dogs admitted to an intensive care unit. J Am Vet Med Assoc 1999;215:798-804.

5. Mammen EF. Disseminated intravascular coagulation (DIC). Clin Lab Sci 2000;13:239-245.

6. Latimer KS, Mahaffey EA, Prasse KW, et al. Hemostasis. In: Duncan & Prasse's veterinary laboratory medicine: clinical pathology. 4th ed. Ames: Iowa State Press, 2003:99-135.

7. Stokol T, Brooks MB, Erb HN, et al. D-dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation. Am J Vet Res 2000;61:393-398.

8. Levi M. Cancer and DIC. Haemostasis 2001;31(suppl 1):47-48.

9. Asakura H, Suga Y, Aoshima K, et al. Marked difference in pathophysiology between tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats. Crit Care Med 2002;30:161-164.

10. Stokol T, Brooks M, Erb H, et al. Evaluation of kits for the detection of fibrin(ogen) degradation products in dogs. J Vet Intern Med 1999;13:478-484.

11. Greene CE. Disseminated intravascular coagulation in the dog: a review. J Am Anim Hosp Assoc 1975;11:674-687.

12. Hackner SG. Approach to the diagnosing of bleeding disorders. Compend Contin Educ Pract Vet 1995;17:331-349.

13. Breazile JE, College of Veterinary Medicine, Oklahoma State University, Stillwater, Okla: Personal communication, 2004.

14. Triplett DA. Coagulation and bleeding disorders: review and update. Clin Chem 2000;46:1260-1269.

15. Hack CE. Derangements of coagulation and fibrinolysis in infectious diseases. Contrib Microbiol 2003;10:18-37.

16. Levi M. Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient. J Crit Care 2001;16:167-177.

17. ten Cate H. Pathophysiology of disseminated intravascular coagulation in sepsis. Crit Care Med 2000;28(suppl 9):S9-S11.

18. Rozanski EA, Hughes D, Scotti M, et al. The effect of heparin and fresh frozen plasma on plasma antithrombin III activity, prothrombin time and activated partial thromboplastin time in critically ill dogs. J Vet Emerg Critic Care 2001;11:15-21.

19. Aoki Y, Ota M, Katsuura Y, et al. Effect of activated human protein C on disseminated intravascular coagulation induced by lipopolysaccharide in rats. Arzneimittelforschung 2000;50:809-815.

20. Izutani W, Fujita M, Nishizawa K, et al. Urinary protein C inhibitor as a therapeutic agent to disseminated intravascular coagulation (DIC): a comparison with low molecular weight heparin in rats with lipopolysaccharide-induced DIC. Biol Pharm Bull 2000;23:1046-1050.


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