On the Forefront: Extended-release liposomal opioids for treating pain in dogs - Veterinary Medicine
Medicine Center
DVM Veterinary Medicine Featuring Information from:


On the Forefront: Extended-release liposomal opioids for treating pain in dogs


5. Dohoo S. Steady-state pharmacokinetics of oral sustained-release morphine sulphate in dogs. J Vet Pharmacol Ther 1997;20:129-133.

6. Kyles AE, Papich M, Hardie EM. Disposition of transdermally administered fentanyl in dogs. Am J Vet Res 1996;57:715-719.

7. Hardwick WE Jr, King WD, Palmisano PA. Respiratory depression in a child unintentionally exposed to transdermal fentanyl patch. South Med J 1997;90:962-964.

8. Purucker M, Swann W. Potential for duragesic patch abuse. Ann Emerg Med 2000;35:314.

9. Smith LJ, Krugner-Higby L, Clark M, et al. A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain. Comp Med 2003;53:280-287.

10. Krugner-Higby L, Smith LJ, Clark M, et al. Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of postsurgical visceral pain in rats. Comp Med 2003;53:270-279.

11. Clark MD, Krugner-Higby L, Smith LJ, et al. Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy. Comp Med 2004;54:558-563.

12. Smith LJ, Krugner-Higby L, Trepanier LA, et al. Sedative effects and serum drug concentrations of oxymorphone and metabolites after subcutaneous administration of a liposome-encapsulated formulation in dogs. J Vet Pharmacol Ther 2004;27:369-372.

The information for "On the Forefront" was provided by Lesley J. Smith, DVM, DACVA, Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.


Click here