Conclusion

Renal transitional cell carcinoma is a rare tumor in cats that has aggressive biologic behavior but can initially present with vague, nonspecific signs. Generally, the clinical signs are decreased appetite, weight loss, hematuria, or pyuria. Once a renal mass is recognized, initial diagnosis of renal tumors can be made by fine-needle aspirate cytology. This simple procedure can help identify cats that may benefit from nephrectomy. However, histologic confirmation should always be obtained after surgery, as the long-term prognosis varies with specific tumor type.

Andrew R. Lie, DVM*
Blaine Area Pet Hospital
11844 Aberdeen St. NE
Blaine, MN 55449

Current addresses:
*Mission Pet Hospital
720 Valencia St.
San Francisco, CA 94110

**Pet Emergency and Specialty Center of Marin
901 E. Francisco Blvd., Suite C
San Rafael, CA 94901

REFERENCES

1. Henry CJ, Turnquist SE, Smith A, et al. Primary renal tumours in cats: 19 cases (1992-1998). J Feline Med Surg 1999;1:165-170.

2. Knapp DW. Tumors of the urinary system. In: Withrow SJ, MacEwan EG, eds. Small animal clinical oncology. Philadelphia, Pa: WB Saunders Co, 2001;490-499.

3. Moore AS, Ogilvie GK. Tumors of the urinary tract. In: Ogilvie GK, Moore AS, eds. Feline oncology: a comprehensive guide to compassionate care. Trenton, NJ: Veterinary Learning Systems, 2001;311-317.

4. Militerno G, Bazzo R, Bevilacqua D, et al. Transitional cell carcinoma of the renal pelvis in two dogs. J Vet Med A Physiol Pathol Clin Med 2003;50:457-459.

5. DiBartola SP. Renal disease: clinical approach and laboratory evaluation. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. St. Louis, Mo: Elsevier Saunders, 2005;1716-1730.

6. Ogilvie GK, Moore AS, Obradovich JE, et al. Toxicoses and efficacy associated with administration of mitoxantrone to cats with malignant tumors. J Am Vet Med Assoc 1993;202:1839-1844.

7. Crespi MD, Ivanier SE, Genovese J, et al. Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem Biophys Res Commun 1986;136:521-528.

8. Kochevar DT, Middendorf DL, Mealey KL, et al. Pharmacokinetics and haematological effects of a single intravenous dose of mitoxantrone in cats. J Vet Pharmacol Ther 1995;18:471-475.

9. Heeb HL, Chun R, Koch DE, et al. Single dose pharmacokinetics of piroxicam in cats. J Vet Pharmacol Ther 2003;26:259-263.

10. Kern TJ, Aromando MC, Erb HN. Horner's syndrome in dogs and cats: 100 cases (1975-1985). J Am Vet Med Assoc 1989;195:369-373.

11. Morgan RV, Zanotti, SW. Horner's syndrome in dogs and cats: 49 cases (1980-1986). J Am Vet Med Assoc 1989;194:1096-1099.

12. Pedroia V. Deficits of function due to peripheral cranial neuropathies. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. St. Louis, Mo: Elsevier Saunders, 2005;171-175.

13. Forrest LJ, Graybush CA. Radiographic patterns of pulmonary metastasis in 25 cats. Vet Radiol Ultrasound 1998;39:4-8.

14. Prather AB, Berry CR, Thrall DE. Use of radiography in combination with computed tomography for the assessment of noncardiac thoracic disease in the dog and cat. Vet Radiol Ultrasound 2005;46:114-121.

15. Henninger W. Use of computed tomography in the diseased feline thorax. J Small Anim Pract 2003;44:56-64.