Pimobendan: Understanding its cardiac effects in dogs with myocardial disease - Veterinary Medicine
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Pimobendan: Understanding its cardiac effects in dogs with myocardial disease
When used in conjunction with other cardiac drugs, pimobendan, unapproved for use in the United States, may benefit dogs with congestive heart failure secondary to dilated cardiomyopathy or valvular insufficiency.



1. Lefbon BK. Sildenafil and novel cardiovascular therapies, in Proceedings. Am Coll Vet Intern Med 2005.

2. Hagemeijer F. Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure. Eur Heart J 1993;14:551-566.

3. Fuentes VL. Use of pimobendan in the management of heart failure. Vet Clin North Am Small Anim Pract 2004;34:1145-1155.

4. Chu KM, Shieh SM, Hu OY. Pharmacokinetics and pharmacodynamics of enantiomers of pimobendan in patients with dilated cardiomyopathy and congestive heart failure after single and repeated oral dosing. Clin Pharmacol Ther 1995;57:610-621.

5. Breazile JE, College of Veterinary Medicine, Oklahoma State University, Stillwater, Okla: Personal communication, 2006.

6. Fox PR, Sisson D, Moise NS. Myocardial diseases of dogs. In: Textbook of canine and feline cardiology. 2nd ed. Philadelphia, Pa: WB Saunders Co, 1999;581-620.

7. Goto Y, Hata K. Mechanoenergetic effect of pimobendan in failing dog hearts. Heart Vessels 1997;12(suppl):103-105.

8. Opie LH. Myocardial contraction and relaxation. In: Heart physiology: from cell to circulation. 4th ed. New York, NY: Lippincott Williams & Wilkins, 2004;221-246.

9. Ruegg JC. Effects of new inotropic agents on Ca++ sensitivity of contractile proteins. Circulation 1986;73:III78-III84.

10. Matthew L, Katz S: Calcium sensitizing agents in heart failure. Drugs Aging 1988;12:191-204.

11. Kleeman R, Lebobinnee G, Bruyere D, et al. Clinical efficacy of the novel inodilator pimobendan in dogs suffering from congestive heart failure, in Proceedings. Br Small Anim Vet Congress 1998.

12. Fuentes VL, Corcoran B, French A, et al. A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy. J Vet Intern Med 2002;16:255-261.

13. Smith PJ, French AT, Van Israel N, et al. Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. J Small Anim Pract 2005;46:121-130.

14. Lombard CW, Jons O, Bussadoril CM. Clinical efficacy of pimobendan versus benazepril for the treatment of acquired atrioventricular valvular disease in dogs. J Am Anim Hosp Assoc 2006;42:249-261.

15. Aiba T, Ishida K, Yoshinaga M, et al. Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers. Biol Pharm Bull 2005;28:114-119.

16. Rosenthal SL, Ferguson MJ, Lefbom BK, et al. Association of pimobendan with ventricular arrhythmias in dogs with congestive heart failure, in Proceedings. Am Coll Vet Intern Med 2006.


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