Toxicology Brief: Breathe with ease when managing beta-2 agonist inhaler toxicoses in dogs - Veterinary Medicine
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Toxicology Brief: Breathe with ease when managing beta-2 agonist inhaler toxicoses in dogs

Duration of signs

The endpoint of therapy is resolution of the abnormal clinical findings. We can estimate the duration of signs based on exposure evidence and metabolism and excretion data extrapolated from human exposure. The plasma half-life in people for inhaled albuterol is about 3.8 hours (1.7- to 7.1-hour range in a separate study).14 Albuterol is metabolized in the liver to the relatively inactive albuterol 4'-O-sulfate. Excretion of the parent drug and metabolites occurs rapidly, predominantly through the kidneys,14 but about 10% is excreted in the feces.9 Most dogs with mild signs recover within 12 hours of exposure with appropriate supportive care, but signs can persist for 24 to 48 hours with large overdoses.

SUMMARY

The immediate delivery of massive amounts of beta2 agonists from inhalers punctured by dogs warrants prompt veterinary attention. Clinical signs reported in such exposures are fairly predictable; lethargy, tachypnea, agitation, and trembling are among the most common. Tachycardia is the most consistent clinical finding. Be aware of the potential for this type of toxicosis and recognize it as a possible cause when signs consistent with beta2 agonist overdose are encountered. With appropriate monitoring of vital signs and electrolytes, supportive care, and administration of pharmaceuticals to mitigate the adverse effects, toxicoses due to albuterol and other beta2 agonists can be managed successfully. However, when existing cardiac disease is present or the toxicosis is compounded by the concurrent use of tricyclic antidepressants, monoamine oxidase inhibitors, or digoxin, complications such as cardiac decompensation or sudden death may occur.

"Toxicology Brief" was contributed by Donna Mensching, DVM, and Petra A. Volmer, MS, DVM, DABVT, DABT, Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802. Dr. Volmer is the editor of "Toxicology Brief."

REFERENCES

1. Castro HJ, Malka-Rais J, Bellanti, JA. Current epidemiology of asthma: emerging patterns of asthma. Allergy Asthma Proc 2005;26:79-82.

2. American Veterinary Medical Association. Veterinary market statistics: U.S. pet ownership & demographics sourcebook;80.

3. Landsberg L, Young JB. Pharmacology of the sympathoadrenal system. In: Braunwald MD, ed. Harrison's principles of internal medicine. 15th ed. New York, NY: McGraw Hill, 2001;443-448.

4. Physicians' Desk Reference. 56th ed. Montvale, NJ: Medical Economics Company, 2002;308,309,318,1029,1041,1679.

5. Stiles J, Plumb D. Toxicity associated with beta-agonist aerosol exposure in three dogs. J Am Anim Hosp Assoc 1993;29:235-238.

6. Plumb DC. Veterinary drug handbook. 5th ed. Stockholm, Wis: PharmaVet Inc, 2005;15-16,36,188,410,697,877.

7. Vite CH, Gfeller RW. Suspected albuterol intoxication in a dog. J Vet Emerg Crit Care 1994;4:7-12.

8. GlaxoSmithKline, Customer Service, 1-888-825-5249, personal communication, June 13, 2005.

9. Rosendale M. Bronchodilators. In: Plumlee KH, ed. Clinical veterinary toxicology. Philadelphia, Pa: Mosby Inc, 2004;305-307.

10. Petruska JM, Beattie JG, Stuart BO, et al. Cardiovascular effects after inhalation of large doses of albuterol dry powder in rats, monkeys, and dogs: a species comparison. Fundam Appl Toxicol 1997;40:52-62.


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