What's new in dermatologic therapy? - Veterinary Medicine
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What's new in dermatologic therapy?
Five new drugs show promise in treating dermatomyositis, atopic dermatitis, papillomavirus infection, and more. Find out if they should be in your treatment arsenal.


VETERINARY MEDICINE



Figure 4. Papillomavirus infection near a footpad in a dog (before therapy) that responded to imiquimod.
In our practice, imiquimod has been used successfully to treat two forms of canine papillomavirus infection (Figure 4), feline herpesvirus infection, feline papillomas, feline Bowen's disease, and equine sarcoids. No side effects have been seen so far. The drug may be helpful for solar dermatitis and precancerous solar-induced lesions in dogs and cats if the lesions are localized. Irritancy seems to be an individual response, with horses and cats seemingly more sensitive than dogs. We are applying it topically from two to four consecutive days a week at a dose of one packet (0.25 g) given over two or three days. Generally we only treat some of the lesions and have seen untreated lesions also respond. It is available in boxes containing 12 doses for about $140, and a single dose can be dispensed to use for multiple applications.

Heide M. Newton, DVM, DACVD
Craig E. Griffin, DVM, DACVD
Animal Dermatology Clinic
5610 Kearny Mesa Road
San Diego, CA 92111

REFERENCES

1. Samlaska CP, Winfield EA. Pentoxifylline. J Am Acad Dermatol 1994;30(4):603-621.

2. Bruynzeel I, van der Raaij LM, Stoof TJ, et al. Pentoxifylline inhibits T-cell adherence to keratinocytes. J Invest Dermatol 1995;104(6):1004-1007.

3. Marsella R, Nicklin CF. Double-blinded cross-over study on the efficacy of pentoxifylline for canine atopy. Vet Dermatol 2000;11:255-260.

4. Rees CA, Boothe DM. Therapeutic response to pentoxifylline and its active metabolites in dogs with familial canine dermatomyositis. Vet Ther 2003;4(3):234-241.

5. Marsella R, Kunkle GA, et al. Use of pentoxifylline in the treatment of allergic contact reactions to plants of the Commelinceae family in dogs. Vet Dermatol 1997;8:121-126.

6. Nichols PR, Morris DO, Beale KM. A retrospective study of canine and feline cutaneous vasculitis. Vet Dermatol 2001;12(5):255-264.

7. Mueller RS, Rosychuk RA, Jonas LD. A retrospective study regarding the treatment of lupoid onychodystrophy in 30 dogs and literature review. J Am Anim Hosp Assoc 2003;39(2):139-150.

8. Jackson HA. Eleven cases of vesicular cutaneous lupus erythematosus in Shetland sheepdogs and rough collies: clinical management and prognosis. Vet Dermatol 2004;15(1):37-41.

9. Marsella R, Olivry T. The ACVD task force on canine atopic dermatitis (XXII): nonsteroidal anti-inflammatory pharmacotherapy. Vet Immunol Immunopathol 2001;81(3-4):331-345.

10. Rees CA, Boothe DM, Boeckh A, et al. Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs. Vet Ther 2003;4(2):188-196.

11. Marsella R, Nicklin CF, Munson JW, et al. Pharmacokinetics of pentoxifylline in dogs after oral and intravenous administration. Am J Vet Res 2000;61(6):631-637.

12. White SD, Papich M. Update on dermatological therapy, in Proceedings. Am Acad Vet Dermatol/Am Coll Vet Dermatol Annu Mtg 2002.

13. Marsella R, Nicklin CF. Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. Vet Dermatol 2002;13(4):203-210.


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