Ophthalmic drugs: What's new? - Veterinary Medicine
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Ophthalmic drugs: What's new?
Have you considered trying a lacrimomimetic agent to treat KCS or a topical prostaglandin analogue to reduce IOP? This overview of selected pharmaceuticals will help you choose what to prescribe for patients with ocular disease.


VETERINARY MEDICINE


Wendy M. Townsend, DVM, MS, DACVO
Department of Small Animal Clinical Sciences
College of Veterinary Medicine
Michigan State University
East Lansing, MI 48824

REFERENCES

1. Rao A. NFATp, a cyclosporine-sensitive transcription factor implicated in cytokine gene induction. J Leukoc Biol 1995;57:536-542.

2. Kaswan RL, Salisbury MA, Ward DA. Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops. Arch Ophthalmol 1989;107:1210-1216.

3. Berdoulay A, English RV, Nadelstein B. Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca. Vet Ophthalmol 2005;8:225-232.

4. Nell B, Walde I, Billich A, et al. The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. Vet Ophthalmol 2005;8:39-46.

5. Grahn BH, Storey ES. Lacrimostimulants and lacrimomimetics. Vet Clin North Am Small Anim Pract 2004;34:739-753.

6. Yu-Speight AW, Kern TJ, Erb HN. Ciprofloxacin and ofloxacin aqueous humor concentrations after topical administration in dogs undergoing cataract surgery. Vet Ophthamol 2005;8:181-187.

7. Mather R, Karenchak LM, Romanowski EG, et al. Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Am J Ophthalmol 2002;133:463-466.

8. Kern TJ. Antibacterial agents for ocular therapeutics. Vet Clin North Am Small Anim Pract 2004;34:655-668.

9. Galle LE. Antiviral therapy for ocular viral disease. Vet Clin North Am Small Anim Pract 2004;34:639-653.

10. Fontenelle J, Powell C, Gionfriddo J, et al. Effect of topical cidofovir on experimentally induced FHV-1 conjunctivitis (abstract). Vet Ophthalmol 2005;8:444.

11. Thomasy S, Maggs D, Lim C, et al. Safety and efficacy of famciclovir in cats infected with feline herpesvirus 1, in Proceedings. 37th Annu Conf Am Coll Vet Ophthalmol 2006;43.

12. Stiles J, Townsend WM, Rogers QR, et al. Effect of oral administration of L-lysine on conjunctivitis caused by feline herpesvirus in cats. Am J Vet Res 2002;63:99-103.

13. King TC, Gum GG, Gelatt KN. Evaluation of a topically administered carbonic anhydrase inhibitor (MK-927) in normotensive and glaucomatous beagles. Am J Vet Res 1991;52:2067-2070.

14. Gelatt KN, MacKay EO. Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet Ophthalmol 2001;4:61-67.

15. Studer ME, Martin CL, Stiles J. Effects of 0.005% latanoprost solution on intraocular pressure in healthy dogs and cats. Am J Vet Res 2000;61:1220-1224.

16. Xalatan [package insert]. Pharmacia and Upjohn, Division of Pfizer Inc., New York, NY.

17. Carvalho AB, Laus JL, Costa VP, et al. Effects of travoprost 0.004% compared with latanoprost 0.005% on the intraocular pressure of normal dogs. Vet Ophthalmol 2006;9:121–125.

18. Willis AM, Diehl KA, Hoshaw-Woodard S, et al. Effects of topical administration of 0.005% latanoprost solution on eyes of clinically normal horses. Am J Vet Res 2001;62:1945-1951.


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