Toxicology Brief: The critical care of aflatoxin-induced liver failure in dogs - Veterinary Medicine
Medicine Center
DVM Veterinary Medicine Featuring Information from:


Toxicology Brief: The critical care of aflatoxin-induced liver failure in dogs


12. Lee NA, Wang S, Allan RD, et al. A rapid aflatoxin B1 ELISA: development and validation with reduced matrix effects for peanuts, corn, pistachio, and Soybeans. J Agric Food Chem 2004;52:2746-2755.

13. Stenske KA, Smith JR, Newman SJ, et al. Aflatoxicosis in dogs and dealing with suspected contaminated commercial foods. J Am Vet Med Assoc 2006;228:1686-1691.

14. U.S. Food and Drug Administration. FDA issues consumer alert on contaminated pet food. Available at: http:// Accessed Jan 15, 2007.

15. Ketterer PJ, Williams ES, Blaney BJ, et al. Canine aflatoxicosis. Aust Vet J 1975;51:355-357.

16. Liggett AD, Colvin BM, Beaver RW, et al. Canine aflatoxicosis: a continuing problem. Vet Hum Toxicol 1986;28:428-430.

17. Bastianello SS, Nesbit JW, Williams MC, et al. Pathological findings in a natural outbreak of aflatoxicosis in dogs. Onderstepoort J Vet Res 1987;54:635-640.

18. Hagiwara MK, Kogika MM, Malucelli BE. Disseminated intravascular coagulation in dogs with aflatoxicosis. J Small Anim Pract 1990;31:239-243.

19. Bingham AK, Huebner HJ, Phillips TD, et al. Identification and reduction of urinary aflatoxin metabolites in dogs. Food Chem Toxicol 2004;42:1851-1858.

20. Gallagher EP, Kunze KL, Stapleton PL, et al. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol 1996;141:595-606.

21. Neal GE, Eaton DL, Judah DJ, et al. Metabolism and toxicity of aflatoxins M1 and B1 in human-derived in vitro studies. Toxicol Appl Pharmacol 1998;151:152-158.

22. Raney KD, Meyer DJ, Ketterer B, et al. Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. Chem Res Toxicol 1992;5:470-478.

23. Zwingmann C, Bilodeau M. Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver. Hepatology 2006;43:454-463.

24. Valdivia AG, Martinez A, Damian FJ, et al. Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poult Sci 2001;80:727-734.

25. DeFlora S, Bennicelli C, Camoirano A, et al. In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 1985;6:1735-1745.

26. Eraslan G, Cam Y, Eren M, et al. Aspects of using N-acetylcysteine in aflatoxicosis and its evaluation regarding some lipid peroxidation parameters in rabbits. Bull Vet Inst Pulawy 2005;49:243-247. Available at:

27. Plumb DC. Acetylcysteine. In: Plumb DC, ed. Plumb's veterinary drug handbook. 5th ed. Ames, Iowa: Blackwell Publishing Professional, 2005;9-10.


Click here