Pimobendan treatment in dogs with congestive heart failure - Veterinary Medicine
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Pimobendan treatment in dogs with congestive heart failure
When used in conjunction with other cardiac drugs, pimobendan may benefit dogs with congestive heart failure secondary to dilated cardiomyopathy or degenerative valve disease.


VETERINARY MEDICINE


CONCLUSION

Pimobendan is an inodilator used to treat overt or impending congestive heart failure in dogs. Studies have either demonstrated or suggested a favorable influence when pimobendan is used as adjunctive therapy (e.g. with an ACE inhibitor, furosemide, digoxin) in patients with advanced dilated cardiomyopathy or degenerative mitral valve disease.9,13,14 In our experience with more than 100 dogs, pimobendan is well-tolerated and has few adverse effects. Pimobendan should not be used as a replacement for, but rather as cotherapy with, other cardiac drugs to enhance the quality of life in dogs with overt or impending congestive heart failure.

Justin D. Thomason, DVM, DACVIM (small animal internal medicine)
Department of Clinical Sciences
Center for Veterinary Health Sciences
Oklahoma State University
Stillwater, OK 74078

Tiffany K. Fallaw, BS, RVT
Clay Calvert, DVM, DACVIM (small animal internal medicine)
Department of Small Animal Medicine and Surgery
College of Veterinary Medicine
University of Georgia
Athens, GA 30605

REFERENCES

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5. Breazile JE, College of Veterinary Medicine, Oklahoma State University, Stillwater, Okla: Personal communication, 2006.

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9. Boehringer Ingelheim Vetmedica. Vetmedin (pimobendan) tablets package insert. St. Joseph, Mo., 2007.

10. Aiba T, Ishida K, Yoshinaga M, et al. Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in CACO-2 cell monolayers. Biol Pharm Bull 2005;28:114-119.

11. Rosenthal SL, Ferguson MJ, Lefbom BK, et al. Association of pimobendan with ventricular arrhythmias in dogs with congestive heart failure, in Proceedings. Am Coll Vet Intern Med 2006.

12. Ruegg JC. Effects of new inotropic agents on Ca++ sensitivity of contractile proteins. Circulation 1986;73:III78-III84.

13. Fuentes VL, Corcoran B, French A, et al. A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy. J Vet Intern Med 2002;16:255-261.

14. Smith PJ, French AT, Van Israel N, et al. Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. J Small Anim Pract 2005;46:121-130.


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