A challenging case: Glucagonoma-associated superficial necrolytic dermatitis in a dog - Veterinary Medicine
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A challenging case: Glucagonoma-associated superficial necrolytic dermatitis in a dog
Although this skin disease is usually associated with hepatopathy, in this dog the lesions had a more uncommon cause.


VETERINARY MEDICINE


Kurt L. Zimmerman, DVM, PhD
Department of Biomedical Sciences & Pathobiology
Virginia-Maryland Regional College of Veterinary Medicine
Virginia Tech
Blacksburg, VA 24061

Shawn P. Clark, DVM, PhD, DACVP
Bristol-Myers Squibb
2400 W. Lloyd Expressway
Evansville, IN 47721

Kate Hill, BVSc(Hons), DACVIM
Veterinary Teaching Hospital
Massey University
Palmerston North, New Zealand

Peter Laverty, BVSc, MACVSc, DACVS
Melbourne Veterinary Specialist Centre
70 Blackburn Road
Glen Waverley, VIC 3150, Australia

Armando Irizarry, DVM, PhD, DACVP
Eli Lilly & CO
2001 W. Main St.
Greenfield, IN 46140

Tanya LeRoith, DVM, PhD, DACVP
Department of Biomedical Sciences & Pathobiology
Virginia-Maryland Regional College of Veterinary Medicine
Virginia Tech
Blacksburg, VA 24061

Dennis DeNicola, DVM, PhD, DACVP
IDEXX Laboratories
1 IDEXX Drive
Westbrook, ME 04092

REFERENCES

1. Sherwin RS, Hendler R, DeFronzo R, et al. Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proc Natl Acad Sci USA 1997;74:348-352.

2. Chastain MA. The glucagonoma syndrome: a review of its features and discussion of new perspective. Am J Med Sci 2001;321:306-320.

3. Bloom SR, Polak JM. Glucagonoma syndrome. Am J Med 1987;82(5B):25-36.

4. Wermers RA, Fatourechi V, Wynne AG, et al. The glucagonoma syndrome. Clinical and pathologic features in 21 patients. Medicine (Baltimore) 1996;75:53-63.

5. Allenspach K, Arnold P, Glaus T, et al. Glucagon-producing neuroendocrine tumour associated with hypoaminoacidaemia and skin lesions. J Small Anim Pract 2000;41:402-406.

6. Turek MM. Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 2003;14:279-296.

7. Capen C. Tumors of the endocrine gland. In: Moulton J, ed. Tumors in domestic animals. 3rd ed. Berkeley, Calif: University of California Press, 1990;616-623.

8. Cerundolo R, McEvoy F, McNeil PE, et al. Ultrasonographic detection of a pancreatic glucagon-secreting multihormonal islet cell tumour in a dachshund with metabolic epidermal necrosis. Vet Rec 1999;145:662-666.

9. Gross TL, O'Brien TD, Davies AP, et al. Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis. J Am Vet Med Assoc 1990;197:1619-1622.

10. Miller WH, Anderson WI, McCann JP. Necrolytic migratory erythema in a dog with a glucagon-secreting endocrine tumor. Vet Dermatol 1991;2:179-182.

11. Torres S, Johnson K, McKeever P, et al. Superficial necrolytic dermatitis and a pancreatic endocrine tumour in a dog. J Small Anim Pract 1997;38:246-250.

12. Hawkins KL, Summers BA, Kuhajda FP, et al. Immunocytochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs. Vet Pathol 1987;24:170-179.

13. O'Brien TD, Hayden DW, O'Leary TP, et al. Canine pancreatic endocrine tumors: immunohistochemical analysis of hormone content and amyloid. Vet Pathol 1987;24:308-314.

14. Torres SM, Caywood DD, O'Brien TD, et al. Resolution of superficial necrolytic dermatitis following excision of a glucagon-secreting pancreatic neoplasm in a dog. J Am Anim Hosp Assoc 1997;33:313-319.

15. Byrne KP. Metabolic epidermal necrosis-hepatocutaneous syndrome. Vet Clin North Am Small Anim Pract 1999;29:1337-1355.


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