Diagnosing and treating canine copper-associated hepatopathies - Veterinary Medicine
  • SEARCH:
Medicine Center
DVM Veterinary Medicine Featuring Information from:

ADVERTISEMENT

Diagnosing and treating canine copper-associated hepatopathies
Whether from inflammatory hepatic disease or an inherited metabolic defect, copper accumulation can lead to hepatocellular damage and even cirrhosis. Treatment can successfully mitigate or even reverse copper-associated changes.


VETERINARY MEDICINE


REFERENCES

1. Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagn Invest 2000;12(2):101-110.

2. Twedt DC, Sternlieb I, Gilbertson SR. Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers. J Am Vet Med Assoc 1979;175(3):269-275.

3. van De Sluis B, Rothuizen J, Pearson PL, et al. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum Mol Genet 2002;11(2):165-173.

4. Spee B, Arends B, van den Ingh TS, et al. Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs. J Vet Intern Med 2006;20(5):1085-1092.

5. Rolfe DS, Twedt DC. Copper-associated hepatopathies in dogs. Vet Clin North Am Small Anim Pract 1995;25(2):399-417.

6. Guilford WG, Strombeck DR. In: Guilford WG, Center SA, Strombeck DR, et al., eds. Strombeck's small animal gastroenterology. 3rd ed. Philadelphia, Pa: WB Saunders Co, 1996;xiii,978.

7. Mandigers PJ, van den Ingh TS, Bode P, et al. Improvement in liver pathology after 4 months of D-penicillamine in 5 doberman pinschers with subclinical hepatitis. J Vet Intern Med 2005;19(1):40-43.

8. Sartor LL, Trepanier LA. Rational pharmacologic therapy of hepatobiliary disease in dogs and cats. Compend Contin Educ Pract Vet 2003;25:432-447.

9. Seguin MA, Bunch SE. Iatrogenic copper deficiency associated with long-term copper chelation for treatment of copper storage disease in a Bedlington Terrier. J Am Vet Med Assoc 2001;218(10):1593-1597, 1580.

10. Plumb DC. Plumb's veterinary drug handbook. 5th ed. Ames, Iowa: Blackwell Publishing, 2005;929.


ADVERTISEMENT

Source: VETERINARY MEDICINE,
Click here