Exercise intolerance in retrievers - Veterinary Medicine
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Exercise intolerance in retrievers
When a dog from one of the popular retriever breeds is brought to you because it collapsed while exercising or seems to tire easily, you need to sift through the many potential underlying causes. It could be anything from an out-of-shape weekend athlete to a dog with an inherited metabolic myopathy. Here are some of the conditions to consider.



1. American Kennel Club News Article: Labrador Retriever holds firm in top spot on AKC's list of most popular dogs in America. http://www.akc.org/news/. Jan. 21, 2009. Accessed May 27, 2009.

2. Canadian Kennel Club News: The top 20 CKC breeds for 2008. http://www.ckc.ca/en/Default.aspx?tabid=201&NewsID=275&prevID=. Feb. 4, 2009. Accessed June 28, 2009.

3. Impellizeri JA, Tetrick MA, Muir P. Effect of weight reduction on clinical signs of lameness in dogs with hip osteoarthritis. J Am Vet Med Assoc 2000;216(7):1089-1091.

4. Bach JF, Rozanski EA, Bedenice D, et al. Association of expiratory airway dysfunction with marked obesity in healthy adult dogs. Am J Vet Res 2007;68(6):670-675.

5. Johnston SA, McLaughlin RM, Budsberg SC. Nonsurgical management of osteoarthritis in dogs. Vet Clin North Am Small Anim Pract 2008;38(6):1449-1470.

6. Stull JW, Evason M, Carr AP, et al. Canine immune-mediated polyarthritis: clinical and laboratory findings in 83 cases in western Canada. Can Vet J 2008;49:1195-1203.

7. Jacques D, Cauzinille L, Bouvy B, et al. A retrospective study of 40 dogs with polyarthritis. Vet Surg 2002;31(5):428-434.

8. Rondeau MP, Walton RM, Bissett S, et al. Suppurative, nonseptic polyarthropathy in dogs. J Vet Intern Med 2005;19(5):654-662.

9. Hansson-Hamlin H, Lilliehook I. A possible systemic rheumatoid disorder in the Nova Scotia duck tolling retriever. Acta Vet Scand 2009;51(16):1-10.

10. Sharp NJH, Wheeler SJ. Lumbosacral disease. In: Small animal spinal disorders: diagnosis and surgery. 2nd ed. St. Louis, Mo.: Elsevier Mosby, 2005;181-210.

11. Suwankong N, Meij BP, Voorhout G, et al. Review and retrospective analysis of degenerative lumbosacral stenosis in 156 dogs treated by dorsal laminectomy. Vet Comp Orthop Traumatol 2008;21(23):285-293.

12. De Risio L, Thomas WB, Sharp NJ. Degenerative lumbosacral stenosis. Vet Clin North Am Small Anim Pract 2000;30(1):111-132.

13. Taylor SM. Disorders of the spinal cord. In: Nelson RW, Couto CG, eds. Small animal internal medicine. 4th ed. St. Louis, Mo.: Elsevier Mosby, 2009;1065-1091.

14. Strickland KN. Congenital heart disease. In: Tilley LP, Smith FWK, Oyama MA, Sleeper MM, eds. Manual of canine and feline cardiology. St. Louis, Mo.: Elsevier Saunders, 2008; 215-239.

15. Bonagura JD, Lehmkuhl LB. Congenital heart disease. In: Textbook of canine and feline cardiology, 2nd ed. Philadelphia, Pa.: WB Saunders, 1999;471-535.

16. Bright JM, Cali JV. Clinical usefulness of cardiac event recording in dogs and cats examined because of syncope, episodic collapse or intermittent weakness: 60 cases (1997-1999). J Am Vet Med Assoc 2000;216(7):1110-1114.

17. Schrope DP, Kelch WJ. Signalment, clinical signs, and prognostic indicators associated with high-grade second- or third-degree atrioventricular block in dogs: 124 cases (January 1, 1997-December 31, 1997). J Am Vet Med Assoc 2006;228(11):1710-1717.

18. Kraus MS, Calvert CA. Syncope. In: Bonagura JD, Twedt DC, eds. Current veterinary therapy XIV. St. Louis, Mo.: Elsevier Saunders, 2009;709-712.

19. Shaw SP, Rush JE. Canine pericardial effusion: diagnosis, treatment and prognosis. Compend Contin Educ Vet 2007;29(7):405-411.

20. Shaw SP, Rush JE. Canine pericardial effusion: pathophysiology and cause. Compend Contin Educ Vet 2007;29(7):400-403.

21. McKiernan BC. Sounds and signs: localizing respiratory diseases, in Proceedings. 76th Annual Western Vet Conf 2004.

22. Tobias KM, Millard RP. Laryngeal paralysis in dogs. Compend Cont Educ Vet 2009;31(5):212-219.

23. MacPhail CM, Monnet E. Outcome of and postoperative complications in dogs undergoing surgical treatment of laryngeal paralysis: 140 cases (1985-1998). J Am Vet Med Assoc 2001;218:1949-1956.

24. Snelling SR, Edwards GA. A retrospective study of unilateral arytenoid lateralisation in the treatment of laryngeal paralysis in 100 dogs (1992-2000). Aust Vet J 2003;81:464-468.

25. Jeffery ND, Talbot CE, Smith PM, et al. Acquired idiopathic laryngeal paralysis as a prominent feature of generalised neuromuscular disease in 39 dogs. Vet Rec 2006;158:17-21.

26. Hammel SP, Hottinger HA, Novo RE. Postoperative results of unilateral arytenoid lateralization for treatment of laryngeal paralysis in dogs: 39 cases (1996-2002). J Am Vet Med Assoc 2006;228:1215-1220.

27. Morrison WB. Pallor. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 6th ed. St. Louis, Mo.: Elsevier Saunders, 2005;211-215.

28. Johnson RK, Atkins CE. Non-neoplastic causes of canine hypoglycemia. In: RW Kirk, ed. Current veterinary therapy VII. Philadelphia, Pa.: WB Saunders, 1980;1023-1027.

29. Feldman EC, Nelson RW. Beta-cell neoplasia: insulinoma. In: Canine and feline endocrinology and reproduction. 3rd ed. St. Louis, Mo.: Elsevier Saunders, 2004;616-634.

30. Dunayer EK. Hypoglycemia following canine ingestion of xylitol-containing gum. Vet Hum Toxicol 2004;46(2):87-88.

31. Gregory BL, Shelton GD, Bali DS, et al. Glycogen storage disease type IIIa in curly-coated retrievers. J Vet Intern Med 2007;21(1):40-46.

32. Syme HM, Scott-Moncrieff JC. Chronic hypoglycaemia in a hunting dog due to secondary hypoadrenocorticism. J Small Anim Pract 1998;39:348-351.

33. Angle CT, Wakshlag JJ, Gillette RL, et al. Hematologic, serum biochemical, and cortisol changes associated with anticipation of exercise and short duration high-intensity exercise in sled dogs. Vet Clin Pathol 2009;38(3):370-374.

34. Matwichuk CL, Taylor SM, Shmon CL, et al. Changes in rectal temperature and hematologic, biochemical, blood gas and acid-base values in healthy Labrador retrievers before and after strenuous exercise. Am J Vet Res 1999;60(1):88-92.

35. Thompson AL, Scott-Moncrieff JC, Anderson JD. Comparison of classic hypoadrenocorticism with glucocorticoid-deficient hypoadrenocorticism in dogs: 46 cases (1985-2005). J Am Vet Med Assoc 230(8):1190-1194.

36. Hughes AM, Nelson RW, Famula TR, et al. Clinical features and heritability of hypoadrenocorticism in Nova Scotia duck tolling retrievers: 25 cases (1994-2006). J Am Vet Med Assoc 2007;231(3):407-412.

37. Lennon EM, Boyle TE, Grace Hutchins R, et al. Use of basal serum or plasma cortisol concentrations to rule out a diagnosis of hypoadrenocorticism in dogs: 123 cases (2000-2005). J Am Vet Med Assoc 2007;231(3):413-416.

38. Panciera DL. Conditions associated with hypothyroidism. Vet Clin North Am Small Anim Pract 2001;31(5):935-947.

39. Jaggy A, Oliver JE, Ferguson DC, et al. Neurological manifestations of hypothyroidism: a retrospective study of 29 dogs. J Vet Intern Med 1994;8:328-336.

40. Vitale CL, Olby NJ. Neurologic dysfunction in hypothyroid, hyperlipidemic Labrador retrievers. J Vet Intern Med 2007;21(6):1316-1322.

41. Liu S, Tilley PL, Tappe JP, et al. Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983). J Am Vet Med Assoc 1986;189:227-232.

42. Scott-Moncrieff JCR, Guptill-Yoran L. Hypothyroidism. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 6th ed. St. Louis, Mo.: Elsevier Saunders, 2005;1535-1544.

43. Hill RC, Lewis DD, Beale KM, et al. Effects of racing and training on serum thyroid hormone concentrations in racing greyhounds. Am J Vet Res 2001;62(12):1969-1972.

44. Evason MD, Carr AP, Taylor SM, et al. Alterations in thyroid hormone concentrations in healthy sled dogs before and after athletic conditioning. Am J Vet Res 2004;65(3):333-337.

45. Taylor SM. Selected disorders of muscle and the neuromuscular junction. Vet Clin North Am Small Anim Pract 2000;30(1):59-75.

46. Shelton GD. Myasthenia gravis and disorders of neuromuscular transmission. Vet Clin North Am Small Anim Pract 2002;32(1):189-206.

47. Dickinson PJ, Sturges BK, Shelton GD, et al. Congenital myasthenia gravis in smooth-haired miniature dachshund dogs. J Vet Intern Med 2005;19:920-923.

48. Shelton GD, Lindstrom JM. Spontaneous remission in canine myasthenia gravis: implications for assessing human MG therapies. Neurology 2001;57(11):2139-2141.

49. Evans J, Levesque D, Shelton GD. Canine inflammatory myopathies: a clinicopathologic review of 200 cases. J Vet Intern Med 2004;18:679-691.

50. Podell M. Inflammatory myopathies. Vet Clin North Am Small Anim Pract 2002;32(1):147-167.

51. Shelton GD, Engvall E. Muscular dystrophies and other inherited myopathies. Vet Clin North Am Small Anim Pract 2002;32(1):103-124.

52. Blot S. Disorders of the skeletal muscle — canine. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 6th ed. St. Louis, Mo.: Elsevier Saunders, 2005;901-905.

53. Bergman RL, Inzana KD, Monroe WE, et al. Dystrophin deficient muscular dystrophy in a Labrador retriever. J Am Anim Hosp Assoc 2002;38(3):255-261.

54. Ambrosio CE, Fadel L, Gaiad TP, et al. Identification of three distinguishable phenotypes in golden retriever muscular dystrophy. Gen Mol Res 2009;8(2):389-396.

55. Klopp LS, Smith BF. Autosomal recessive muscular dystrophy in Labrador retrievers. Compend Contin Educ Vet 2000;22(2):121-130.

56. Pele M, Tiret L, Kessler JL, et al. SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dogs. Hum Mol Genet 2005;14(11):1417-1427.

57. Cosford KL, Taylor SM, Thompson L, et al. A possible new inherited myopathy in a young Labrador retriever. Can Vet J 2008;49:393-397.

58. Shelton GD, Snead E, Bohm J, et al. A missense mutation in MTM1 gene causes X-linked myotubular myopathy in Labrador retrievers (abst), in Proceedings. Am Coll Vet Intern Med Forum, 2009.

59. Skibild E, Dahlgaard K, Rajpurohit Y, et al. Haemolytic anemia and exercise intolerance due to phosphofructokinase deficiency in related springer spaniels. J Small Anim Pract 2001;42(6):298-300.

60. Harvey JW. Pathogenesis, laboratory diagnosis and clinical implications of erythrocyte enzyme deficiencies in dogs, cats and horses. Vet Clin Pathol 2006;35(2):144-156.

61. Shelton GD, Nyhan WL, Kass PH, et al. Analysis of organic acids, amino acids and carnitine in dogs with lipid storage myopathy. Muscle Nerve 1998;21:1202-1205.

62. Breitschwerdt EB, Kornegay JN, Wheeler SJ, et al. Episodic weakness associated with exertional lactic acidosis and myopathy in Old English Sheepdog littermates. J Am Vet Med Assoc 1992;201:731-735.

63. Olby NJ, Chan KK, Targett MP et al. Suspected mitochondrial myopathy in a Jack Russell terrier. J Small Anim Pract 1997;38:213-216.

64. Abramson CJ, Platt SR, Shelton GD. Pyruvate dehydrogenase deficiency in a Sussex spaniel. J Small Anim Pract 2004;45(3):162-165.

65. Cameron JM, Maj MC, Levandovskiy V, et al. Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiency. Mol Genet Metab 2007;90(1):15-23.

66. Tauro A, Talbot CE, Pratt JNJ, Boydell IP. Suspected mitochondrial myopathy in a Springer spaniel. Vet Rec 2008;163(13):396-397.

67. Paciello O, Maioling P, Fatone G, et al. Mitochondrial myopathy in a German Shepherd dog. Vet Pathol 2003;40:507-511.

68. Jaggy A, Faissler D, Gaillard C, et al. Genetic aspects of idiopathic epilepsy in Labrador retrievers. J Small Anim Pract 1998;39:275-280.

69. Berendt M, Gredal H, Gam Pedersen L, et al. A cross-sectional study of epilepsy in Danish Labrador retrievers: prevalence and selected risk factors. J Vet Intern Med 2002;16:262-268.

70. Berendt M, Gullov CH, Christensen SLK, et al. Prevalence and characteristics of epilepsy in the Belgian shepherd variants Groenendael and Tervueren born in Denmark 1995-2004. Acta Vet Scand 2008;50(1):51,1-7.

71. Patterson EE, Da Y, Mickelson JR, et al. Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas. J Vet Intern Med 2003;17(3):319-325.

72. Heynold Y, Faissler D, Steffen F, et al. Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 Labrador retrievers: a long term study. J Small Anim Pract 1997;38:7-14.

73. Taylor SM, Shmon CL, Shelton GD, et al. Exercise induced collapse of Labrador retrievers: clinical description of the syndrome and preliminary investigation of heritability. J Am Anim Hosp Assoc 2008;44:295-301

74. Taylor SM, Shmon CL, Adams VJ, et al. Evaluations of Labrador retrievers with exercise induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc 2009;45:3-13.

75. Minor KM, Patterson EE, Gross SD, et al. Frequency of the canine exercise induced collapse (EIC) gene in diverse breeds (abst). J Vet Intern Med 2009;23(3):741.

76. Patterson EE, Minor KM, Tchernatynskaia AV, et al. A canine dynamin 1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics 2008;40(10):1235-1239.

77. Jaderlund KH, Orvind E, Johnsson E, et al. A neurologic syndrome in golden retrievers presenting as a sensory ataxic neuropathy. J Vet Intern Med 2007;21:1307-1315.

78. Baranowska I, Jaderlund KH, Nennesmo I, et al. Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr Gene. PLoS Genet 2009;5(5):1-9.

79. de Lahunta A, Ingram JT, Cummings JF, et al. Labrador retriever central axonopathy. Prog Vet Neurol 1994;5:117-122.

80. da Costa RC, Parent JM, Poma R, et al. Multisystem axonopathy and neuronopathy in golden retriever dogs. J Vet Intern Med 2009;23:935-939.

81. Coates JR, O'Brien DP. Inherited peripheral neuropathies in dogs and cats. Vet Clin North Am Small Anim Pract 2004;34:1361-1401.

82. Olby NJ. Tetraparesis. In: Platt SR, Olby NJ, eds. BSAVA manual of canine and feline neurology. 3rd ed. Hoboken, N.J.: Wiley, 2004-;214-236.

83. Morgan MJ, Vite CH, Radhakrishnan A, et al. Clinical peripheral neuropathy associated with diabetes mellitus in three dogs. Can Vet J 2008;49(6):583-586.


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