Immunosuppressive drugs: Beyond glucocorticoids - Veterinary Medicine
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Immunosuppressive drugs: Beyond glucocorticoids
Prednisone is likely your go-to immunosuppressant. But because of associated adverse effects, having more options would help. Azathioprine, cyclosporine, mycophenolate mofetil, and leflunomide are commonly used for treating immune-mediated human diseases and may soon be incorporated into immunosuppressive protocols in veterinary medicine as well.


11. Favrot C, Reichmuth P, Olivry T. Treatment of canine atopic dermatitis with azathioprine: a pilot study. Vet Rec 2007;160(15):520-521.

12. Harkin KR, Phillips D, Wilkerson M. Evaluation of azathioprine on lesion severity and lymphocyte blastogenesis in dogs with perianal fistulas. J Am Anim Hosp Assoc 2007;43(1):21-26.

13. Dewey CW, Coates JR, Ducote JM, et al. Azathioprine therapy for acquired myasthenia gravis in five dogs. J Am Anim Hosp Assoc 1999;35(5):396-402.

14. Rinkardt NE, Kruth SA. Azathioprine-induced bone marrow toxicity in four dogs. Can Vet J 1996;37(10):612-613.

15. Salavaggione OE, Kidd L, Prondzinski JL, et al. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics 2002;12(9):713-724.

16. Kidd LB, Salavaggione OE, Szumlanski CL, et al. Thiopurine methyltransferase activity in red blood cells of dogs. J Vet Intern Med 2004;18(2):214-218.

17. Salavaggione OE, Yang C, Kidd LB, et al. Cat red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. J Pharmacol Exp Ther 2004;308(2):617-626.

18 . Robson D. Review of the pharmacokinetics, interactions and adverse reactions of cyclosporine in people, dogs and cats. Vet Rec 2003;152(24):739-748.

19. House AK, Guitian J, Gregory SP, et al. Evaluation of the effect of two dose rates of cyclosporine on the severity of perianal fistulae lesions and associated clinical signs in dogs. Vet Surg 2006;35(6):543-549.

20. Mathews KA, Sukhiani HR. Randomized controlled trial of cyclosporine for treatment of perianal fistulas in dogs. J Am Vet Med Assoc 1997;211(10):1249-1253.

21. Mathews KA, Ayres SA, Tano CA, et al. Cyclosporin treatment of perianal fistulas in dogs. Can Vet J 1997;38(1):39-41.

22. Misseghers BS, Binnington AG, Mathews KA. Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. Can Vet J 2000;41(8):623-627.

23. Patricelli AJ, Hardie RJ, McAnulty JE. Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs. J Am Vet Med Assoc 2002;220(7):1009-1016.


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