How to handle feline aortic thromboembolism - Veterinary Medicine
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How to handle feline aortic thromboembolism
A blocked artery caused by a thromboembolus occurs in almost one-third of cats with heart disease, resulting in devastating consequences that often start with pelvic limb paralysis. These clinicians help you detect the blockage, explore newer treatment options, recognize which treatments are not recommended, and identify prevention strategies.



1. Laste NJ, Harpster NK. A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977-1993. J Am Anim Hosp Assoc 1995;31(6):492-500.

2. Smith SA, Tobias AH, Jacob KA, et al. Arterial thromboembolism in cats: acute crisis in 127 cases (1992-2001) and long-term management with low-dose aspirin in 24 cases. J Vet Intern Med 2003;17(1):73-83.

3. Peterson EN, Moise NS, Brown CA, et al. Heterogeneity of hypertrophy in feline hypertrophic heart disease. J Vet Intern Med 1993;7(3):183-189.

4. Rush JE, Freeman LM, Fenollosa NK, et al. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990-1999). J Am Vet Med Assoc 2002;220(2):202-207.

5. Atkins CE, Gallo AM, Kurzman ID, et al. Risk factors, clinical signs, and survival in cats with a clinical diagnosis of idiopathic hypertrophic cardiomyopathy: 74 cases (1985-1989). J Am Vet Med Assoc 1992;201(4):613-618.

6. Fox PR, Maron BJ, Basso C, et al. Spontaneously occurring arrhythmogenic right ventricular cardiomyopathy in the domestic cat: a new animal model similar to the human disease. Circulation 2000;102(15):1863-1870.

7. Cote E, Harpster NK, Laste NJ, et al. Atrial fibrillation in cats: 50 cases (1979-2002). J Am Vet Med Assoc 2004;225(2):256-260.

8. Kittleson MD, Kienle RD. Thromboembolic disease. In: Small animal cardiovascular medicine. St. Louis, Mo: Mosby, 1998;540-547.

9. Smith SA, Tobias AH. Feline arterial thromboembolism: an update. Vet Clin North Am Small Anim Pract 2004;34(5):1245-1271.

10. Sykes JE. Ischemic neuromyopathy due to peripheral arterial embolization of an adenocarcinoma in a cat. J Feline Med Surg 2003;5(6):353-356.

11. Hogan DF, Dhaliwal RS, Sisson DD, et al. Paraneoplastic thrombocytosis-induced systemic thromboembolism in a cat. J Am Anim Hosp Assoc 1999;35(6):483-486.

12. Ibarrola P, German AJ, Stell AJ, et al. Appendicular arterial tumor embolization in two cats with pulmonary carcinoma. J Am Vet Med Assoc 2004;225(7):1065-1069, 1048-1069.

13. Schober KE, Maerz I. Doppler echocardiographic assessment of left atrial appendage flow velocities in normal cats. J Vet Cardiol 2005;7(1):15-25.

14. Schober KE, Maerz I. Assessment of left atrial appendage flow velocity and its relation to spontaneous echocardiographic contrast in 89 cats with myocardial disease. J Vet Intern Med 2006;20(1):120-130.

15. Black IW. Spontaneous echo contrast: where there's smoke there's fire. Echocardiography 2000;17(4):373-382.

16. Bedard C, Lanevschi-Pietersma A, Dunn M. Evaluation of coagulation markers in the plasma of healthy cats and cats with asymptomatic hypertrophic cardiomyopathy. Vet Clin Pathol 2007;36(2):167-172.

17. Stokol T, Brooks M, Rush JE, et al. Hypercoagulability in cats with cardiomyopathy. J Vet Intern Med 2008;22(3):546-552.

18. Ohta K, Gotoh F, Tomita M, et al. Animal species differences in erythrocyte aggregability. Am J Physiol 1992;262(4 Pt 2):H1009-H1012.

19. Helenski CA, Ross JN Jr. Platelet aggregation in feline cardiomyopathy. J Vet Intern Med 1987;1(1):24-28.

20. Watson T, Shantsila E, Lip GYH. Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited. Lancet 2009;373:155-166.

21. Krishnamoorthy S, Lim SH, Lip GY. Assessment of endothelial (dys)function in atrial fibrillation. Ann Med 2009;41(8):576-590.

22. Schaub RG, Meyers KM, Sande RD, et al. Inhibition of feline collateral vessel development following experimental thrombolic occlusion. Circ Res 1976;39(5):736-743.

23. Schaub RG, Meyers KM, Sande RD. Serotonin as a factor in depression of collateral blood flow following experimental arterial thrombosis. J Lab Clin Med 1977;90(4):645-653.

24. Schaub RG, Gates KA, Roberts RE. Effect of aspirin on collateral blood flow after experimental thrombosis of the feline aorta. Am J Vet Res 1982;43(9):1647-1650.

25. McMicheal M, Moore RM. Ischemia-reperfusion injury pathophysiology, part I. J Vet Emerg Crit Care 2004;14(4):231-241.

26. Cauwels A. Nitric oxide in shock. Kidney Int 2007;72(5):557-565.

27. Seal JB, Gewertz BL. Vascular dysfunction in ischemia-reperfusion injury. Ann Vasc Surg 2005;19(4):572-584.

28. Aroch I, Keidar I, Himelstein A, et al. Diagnostic and prognostic value of serum creatine-kinase activity in ill cats: a retrospective study of 601 cases. J Feline Med Surg 2010;12(6):466-475.

29. Wegner K, Robertson SA, Kollias-Baker C, et al. Pharmacokinetic and pharmacodynamic evaluation of intravenous hydromorphone in cats. J Vet Pharmacol Ther 2004;27(5):329-336.

30. Robertson SA, Lascelles BD, Taylor PM, et al. PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration. J Vet Pharmacol Ther 2005;28(5):453-460.

31. Lamont LA. Feline perioperative pain management. Vet Clin North Am Small Anim Pract 2002;32(4):747-763, v.

32. Robertson SA, Lascelles BDX, Taylor P. Effect of 0.1, 0.2, 0.4 and 0.8 mg/kg of IV butorphanol on thermal antinociception in cats. Vet Anaesth Analg 2003;30:108.

33. DiBartola S. Disorders of potassium. In: Fluid, electrolyte, and acid-base disturbances. St. Louis, Mo: Elsevier Health; 2006.

34. Lunsford KV, Mackin AJ. Thromboembolic therapies in dogs and cats: an evidence-based approach. Vet Clin North Am Small Anim Pract 2007;37(3):579-609.

35. Kellerman DL, Lewis DC, Meyers NC, et al. Determination of a therapeutic heparin dosage in the cat. (abstr). J Vet Intern Med 1996;10:231.

36. Thompson MF, Scott-Moncrieff JC, Hogan DF. Thrombolytic therapy in dogs and cats. J Vet Emerg Crit Care 2001;11(2):111-121.

37. Moore KE, Morris N, Dhupa N, et al. Retrospective study of streptokinase administration in 46 cats with arterial thromboembolism. J Vet Emerg Crit Care 2000;10(4):245-257.

38. Welch KM, Rozanski EA, Freeman LM, et al. Prospective evaluation of tissue plasminogen activator in 11 cats with arterial thromboembolism. J Feline Med Surg 2010;12(2):122-128.

39. Koyama H, Matsumoto H, Fukushima RU, et al. Local inter-arterial administration of urokinase in the treatment of a feline distal aortic thromboembolism. J Vet Med Sci 2010;72(9):1209-1211.

40. Reimer SB, Kittleson MD, Kyles AE. Use of rheolytic thrombectomy in the treatment of feline distal aortic thromboembolism. J Vet Intern Med 2006;20(2):290-296.

41. Smith SA, Kraft SL, Lewis DC, et al. Pharmacodynamics of warfarin in cats. J Vet Pharmacol Ther 2000;23(6):339-344.

42. Smith CE, Rozanski EA, Freeman LM, et al. Use of low molecular weight heparin in cats: 57 cases (1999-2003). J Am Vet Med Assoc 2004;225(8):1237-1241.

43. Alwood AJ, Downend AB, Brooks MB, et al. Anticoagulant effects of low-molecular-weight heparins in healthy cats. J Vet Intern Med 2007;21(3):378-387.

44. Vargo CL, Taylor SM, Carr A, et al. The effect of a low molecular weight heparin on coagulation parameters in healthy cats. Can J Vet Res 2009;73(2):132-136.

45. Clarke RJ, Mayo G, Price P, et al. Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. N Engl J Med 1991;325(16):1137-1141.

46. Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation 1999;100(15):1667-1672.

47. Hogan DF, Andrews DA, Talbott KK, et al. Evaluation of antiplatelet effects of ticlopidine in cats. Am J Vet Res 2004;65(3):327-332.

48. Hogan DF, Andrews DA, Green HW, et al. Antiplatelet effects and pharmacodynamics of clopidogrel in cats. J Am Vet Med Assoc 2004;225(9):1406-1411.

49. Hamel-Jolette A, Dunn M, Bedard C. Plateletworks: a screening assay for clopidogrel therapy monitoring in healthy cats. Can J Vet Res 2009;73(1):73-76.


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