CONCLUSION
More research is needed to determine the efficacy of these new barrier-repair topicals. For years, dermatologists have emphasized
grooming, coat hygiene, and bathing as adjunct treatments. The barrier-repair products take that idea one step further. In
our opinion, lipid-containing topicals can be added to almost any atopic dermatitis case without causing harm. They may be
more beneficial when skin infections are under control, since twice weekly bathing could remove the product. It does not seem
likely that they will completely replace conventional therapies, but they may be a useful addition to the atopic dermatitis
treatment arsenal if they can improve the efficacy of allergen-specific immunotherapy and allow for lower doses of glucocorticoids
and cyclosporine.
Jacqueline Gimmler, DVM Jenise Daigle, DVM, DACVD Central Texas Veterinary Specialty Hospital 301 Chisholm Trail Round Rock, TX 78664
REFERENCES
1. Marsella R, Samuelson D. Unraveling the skin barrier: a new paradigm for atopic dermatitis and house dust mites. Vet Dermatol 2009;20:533-540.
2. Lau-Gillard PJ, Hill PB, Chesney CJ, et al. Evaluation of a hand-held evaporimeter (VapoMeter) for the measurement of transepidermal
water loss in healthy dogs. Vet Dermatol 2010;2:136-145.
3. Forslind B, Engstrom S, Engblom J, et al. A novel approach to the understanding of human skin barrier function. J Dermatol Sci 1997;14:115-125.
4. Hightower K, Marsella R, Flynn-Lurie A. Effects of age and allergen exposure on transepidermal water loss in a house dust
mite-sensitized beagle model of atopic dermatitis. Vet Dermatol 2010;21:88-95.
5. Shimada K, Yoon JS, Yoshihara T, et al. Increased transepidermal water loss and decreased ceramide content in lesional and
non-lesional skin of dogs with atopic dermatitis. Vet Dermatol 2009;20:541-546.
6. Reiter LV, Torres SM, Wertz PW. Characterization and quantification of ceramides in the nonlesional skin of canine patients
with atopic dermatitis compared with controls. Vet Dermatol 2009;20:260-266.
7. Olivry T, DeBoer DJ, Favrot C, et al. Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International
Task Force on Canine Atopic Dermatitis. Vet Dermatol 2010;21:233-248.
8. Piekutowska A, Pin D, Reme CA, et al. Effects of a topically applied preparation of epidermal lipids on the stratum corneum
barrier of atopic dogs. J Comp Pathol 2008;138;197-203.
9. Tretter S, Mueller RS. The influence of topical unsaturated fatty acids and essential oils on normal and atopic dogs-a pilot
study. NAVDF 2010 Abstracts. Vet Dermatol 2010;21:311-328.
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