Advances in canine genetic testing—and what these tests mean for you - Veterinary Medicine
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Advances in canine genetic testing—and what these tests mean for you
Genetic testing can reveal a mixed-breed dog's heritage and tell you if a dog carries a gene mutation that could lead to a disease in its offspring. And someday it may even make many of today's genetic diseases a thing of the past.



1. Vila C, Savolainen P, Maldonado JE, et al. Multiple and ancient origins of the domestic dog. Science 1997;276:1687-1689.

2. Vonholdt BM, Pollinger JP, Lohmueller KE, et al. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature 2004;464:898-902.

3. Parker HG, Kim LV, Sutter NB, et al. Genetic structure of the purebred domestic dog. Science 2004;304:1160-1164.

4. Shive RJ, Hare WC, Patterson DF. Chromosome studies in dogs with congenital cardiac defects. Cytogenetics 1965;4:340-348.

5. Kirkness EF, Bafna V, Halpern AL, et al. The dog genome: survey sequencing and comparative analysis. Science 2003;301:1898-1903.

6. Mellersh CS, McLaughlin B, Ahonen S, et al. Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd. Vet Ophthalmol 2009;12:372-378.

7. Todhunter RJ, Mateescu R, Lust G, et al. Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree. Mamm Genome 2005;16:720-730.

8. Phavaphutanon J, Mateescu RG, Tsai KL, et al. Evaluation of quantitative trait loci for hip dysplasia in Labrador Retrievers. Am J Vet Res 2009;70:1094-1101.

9. Marschall Y, Distl O. Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs. Mamm Genome 2007;18:861-870.

10. Miyadera K, Kato K, Aguirre-Hernandez J, et al. Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation. Mol Vis 2009;15:2287-2305.

11. Mars Incorporated. Wisdom Panel Professional Mixed-Breed Genetic Analysis, 2010.

12. Sundberg JP, Boggess D, Silva KA, et al. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol 2003;120:771-775.

13. DNA Breed Identification. Frequently Asked Questions. Available at: Accessed Nov 1, 2011.

14. Happy Dog DNA. Dog DNA Test FAQs. Available at: Accessed Nov 1, 2011.

15. Takeuchi Y, Mori Y. A comparison of the behavioral profiles of purebred dogs in Japan to profiles of those in the United States and the United Kingdom. J Vet Med Sci 2006;68:789-796.

16. Kuska B. Sit, DNA, sit: cancer genetics going to the dogs. J Natl Cancer Inst 1999;91:204-206.

17. College of Veterinary Medicine Veterinary Clinical Pharmacology Lab. Problem drugs. Washington State University, Pullman, Wash., 2009.


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