Both surgical and medical management options are available to treat patients with pyometra, and both carry associated risks.
The decision to pursue medical vs. surgical management should be based on the clinical stability of the bitch as well as on
discussions with the patient's owner concerning the associated risks of treatment and the patient's reproductive value and
potential. Bitches with closed-cervix pyometra are at higher risk for uterine rupture and systemic illness.
INITIAL TREATMENT
Dogs presenting with clinical signs of illness or shock should be appropriately stabilized before direct treatment of the
uterine disease is attempted. The goals of patient stabilization are to restore normal perfusion of the tissues, correct electrolyte
and glucose imbalances, and initiate treatment of infection. Clinically ill patients will benefit from intravenous (IV) fluid
therapy and the administration of parenteral antibiotics. In patients not responding to IV support and medical treatment,
surgical excision of the infected uterus may be required to remove the source of infection and achieve a successful recovery.
The mortality rate associated with pyometra is about 5%, and most of these deaths are due to secondary endotoxemia and shock.1
Bacterial culture and antibiotic susceptibility testing of the uterine contents and urine are recommended in all patients
with pyometra to confirm the effectiveness of empiric antibiotic therapy. Samples for bacterial culture are most commonly
taken from the surgically excised uterus. In those patients undergoing medical management, representative bacterial cultures
may be retrieved from the cranial vagina by using double-guarded swabs. It should be noted that bacteria grown from cranial
vaginal cultures may not be the same as those present in the uterus. The retrieval of samples for bacterial culture and cytologic
evaluation through transcervical endoscopy has also been reported.2
All patients being treated for pyometra should immediately begin empiric bactericidal antibiotic therapy. Amoxicillin-clavulanate,
or a combination of a penicillin and a fluoroquinolone, is a good antibiotic choice based on historical bacterial causes of
uterine infection. The suitability of the empiric antibiotic therapy would then be confirmed by the antibiotic susceptibility
results reported from the patient's original bacterial cultures. Antibiotic therapy should be continued for seven to 14 days
beyond resolution of the patient's pyometra based on physical examination, laboratory, and ultrasonographic findings.3,4
SURGICAL MANAGEMENT
Regardless of cervical patency, ovariohysterectomy is the treatment of choice for dogs with pyometra that are not deemed reproductively
important by their owners.4 The main advantage of ovariohysterectomy over medical management is that it is both curative and preventive for recurrence
of pyometra. A discussion of the ovariohysterectomy procedure is outside the scope of this article and can be reviewed in
any veterinary surgical textbook.
Figure 1. An exteriorized uterus during an ovariohysterectomy for pyometra.
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Ovariohysterectomy carries significant risk, especially in clinically compromised and septic patients. Potential complications
such as low blood pressure, aspiration pneumonia, and cardiac arrhythmia should be discussed with the patient's owner before
anesthetizing the dog. In addition, the uterine walls are often friable and easily torn during manipulation, leading to spillage
of infected contents into the abdomen (Figure 1). A generous abdominal incision allows for easier exposure and exteriorization of the uterus, therefore minimizing the risk
of intra-abdominal rupture. In cases of inadvertent intra-abdominal leakage, abdominal culture followed by copious lavage
with warm saline solution should be performed.
After surgery, patients with pyometra may develop wound infections, fistulous tracts, or local swelling of the surgical incision
site or may hemorrhage.5 Referral to an institution with personnel capable of providing advanced anesthetic monitoring and postoperative care may
be warranted, especially in systemically ill patients that require intensive monitoring.
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