Responding to accidental atomoxetine ingestion - Veterinary Medicine
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Responding to accidental atomoxetine ingestion
At fairly low dosages, atomoxetine—a drug in human medicine to treat ADHD—can be toxic in dogs and cats. Medical management of this toxicosis varies by species.


VETERINARY MEDICINE


CONCLUSION

Fairly low doses of atomoxetine can result in clinical signs in dogs and cats. However, these developments are not expected to be life-threatening with appropriate medical management.

Adrienne Coleman, DVM
ASPCA Animal Poison Control Center
1717 S. Philo Road
Suite 36 Urbana, IL 61802

REFERENCES

1. McEvoy GK. Atomoxetine hydrochloride. In: American Hospital Formulary Service Drug Information. Bethesda, Md: American Society of Health System Pharmacists 2009;2704-2706.

2. Eli Lilly. Strattera prescribing information. Available at: http://pi.lilly.com/us/strattera-pi.pdf. Accessed Feb. 16, 2013.

3. Mattiuz EL, Ponsler GD, Barbuch RJ, et al. Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog. Drug Metab Dispos 2003;31(1):88-97.

4. Michelson D, Faries D, Wernicke J, et al. Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study. Pediatrics 2001;108(5):E83.

5. Porterfield SP. Endocrine physiology. St. Louis, Mo: Mosby-Year Book, 1997;130-133.

6. Clarke DO, Connelly CS, Hall RL, et al. Nonclinical pediatric testing of tomoxetine: toxicity study in young beagle dogs (abst). Neurotoxicol Teratol 2001;23(3):294-295.

7. Plumb DC. Veterinary drug handbook. 6th ed. Stokholm, Wis: PharmaVet, 2005; 4, 91, 235, 368, 794, 886, 962, 1044-1047, 1048, 1253.

8. Plumlee KH. Clinical veterinary toxicology. St. Louis, Mo: Mosby, 2004;15.

9. American Society for the Prevention of Cruelty to Animals Animal Poison Control Center. Unpublished Data 2013. 1717 S. Philo Rd, Ste 36, Urbana, IL 61802.


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