Clinical Rounds: Battling a Labrador's oral malignant melanoma - Veterinary Medicine
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Clinical Rounds: Battling a Labrador's oral malignant melanoma
After a referring veterinarian diagnosed this deadly neoplasm in a senior Labrador retriever, this team of experts stepped in to help extend the dog's life with targeted treatment. What can you learn from their approach to help your patients?


VETERINARY MEDICINE


REFERENCES

1. Smith SH, Goldschmidt MH, McManus PM. A comparative review of melanocytic neoplasms. Vet Pathol 2002;39(6):651-678.

2. Goldschmidt MH. Benign and malignant melanocytic neoplasms of domestic animals. Am J Dermatopathol 1985;7(suppl):203-212.

3. Todoroff RJ, Brodey RS. Oral and pharyngeal neoplasia in the dog: a retrospective survey of 361 cases. J Am Vet Med Assoc 1979;175(6):567-571.

4. Wallace J, Matthiesen DT, Patnaik AK. Hemimaxillectomy for the treatment of oral tumors in 69 dogs. Vet Surg 1992;21(5):337-341.

5. Liptak JM, Withrow SJ. Cancer of the gastrointestinal tract. In: Withrow SJ, Vail DM, eds. Small animal clinical oncology. 4th ed. St. Louis, Mo: Saunders-Elsevier, 2007;455-475.

6. Williams LE, Packer RA. Association between lymph node size and metastasis in dogs with oral malignant melanoma: 100 cases (1987-2001). J Am Vet Med Assoc 2003;222(9):1234-1236.

7. Forrest LJ, Schwarz T. Oral cavity, mandible, maxilla and dental apparatus. In: Schwarz T, Saunders J, eds. Veterinary computed tomography. 1st ed. Ames, Iowa: Wiley-Blackwell, 2011;111-124.

8. Nemanic S, London CA, Wisner ER. Comparison of thoracic radiographs and single breath-hold helical CT for detection of pulmonary nodules in dogs with metastatic neoplasia. J Vet Intern Med 2006;20(3):508-515.

9. Raskin RE. Skin and subcutaneous tissues. In: Raskin RE, Meyer DJ, eds. Canine and feline cytology: a color atlas and interpretation guide. 2nd ed. St. Louis, Mo: Mosby Elsevier, 2010;1-64.

10. Bergman PJ, Kent MS, Farese JP. Melanoma. In: Withrow SJ, Vail DM, Page RL, eds. Small animal clinical oncology. 5th ed. St. Louis, Mo: Mosby Elsevier, 2013;321-334.

11. Esplin DG. Survival of dogs following surgical excision of histologically well-differentiated melanocytic neoplasms of the mucous membranes of the lips and oral cavity. Vet Pathol 2008;45(6):889-896.

12. Schwarz PD, Withrow SJ, Curtis CR, et al. Mandibular resection as a treatment of oral cancer in 81 dogs. J Am Anim Hosp Assoc 1991;27:601-610.

13. Schwarz PD, Withrow SJ, Curtis CR, et al. Partial maxillary resection as a treatment for oral cancer in 61 dogs. J Am Anim Hosp Assoc 1991;27:617-624.

14. Hedlund CS, Tangner CH, Elkins AD, et al. Temporary bilateral carotid artery occlusion during surgical exploration of the nasal cavity of the dog. Vet Surg 1983;12:83.

15. Berg J. Mandibulectomy and maxillectomy. In: Veterinary surgery: small animal. Vol. 2. St. Louis, Mo: Saunders, 2012.

16. Harvey CE. Oral surgery. Radical resection of maxillary and mandibular lesions. Vet Clin North Am Small Anim Pract 1986;16(5):983-993.

17. Matthiesen DT, Manfra Marretta S. Results and complications associated with partial mandibulectomy and maxillectomy techniques. Probl Vet Med 1990;2(1):248-275.

18. Fox LE, Geoghegan SL, Davis LH, et al. Owner satisfaction with partial mandibulectomy or maxillectomy for treatment of oral tumors in 27 dogs. J Am Anim Hosp Assoc 1997;33(1):25-31.

19. Thamm DH, Vail DM. Cancers of the gastrointestinal tract. In: Withrow SJ, Vail DM, eds. Withrow & MacEwen's small animal clinical oncology. 4th ed. St Louis, Mo: Saunders Elsevier, 2007;455-465.

20. Brockley LK, Cooper MA, Bennett PF. Malignant melanoma in 63 dogs (2001-2011): the effect of carboplatin chemotherapy on survival. N Z Vet J 2013;61(1):25-31.

21. Dank G, Rassnick KM, Sokolovsky Y, et al. Use of adjuvant carboplatin for treatment of dogs with oral malignant melanoma following surgical excision. Vet Comp Oncol 2012. [Epub ahead of print]

22. Boria PA, Murry DJ, Bennett PF, et al. Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs. J Am Vet Med Assoc 2004;224(3):388-394.

23. Page RL, Thrall DE, Dewhirst MW, et al. Phase I study of melphalan alone and melphalan plus whole body hyperthermia in dogs with malignant melanoma. Int J Hyperthermia 1991;7(4):559-566.

24. Rassnick KM, Ruslander DM, Cotter SM, et al. Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989-2000). J Am Vet Med Assoc 2001;218(9):1444-1448.

25. Ogilvie GK, Reynolds HA, Richardson RC, et al. Phase II evaluation of doxorubicin for treatment of various canine neoplasms. J Am Vet Med Assoc 1989;195(11):1580-1583.

26. Leach TN, Childress MO, Greene SN, et al. Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Vet Comp Oncol 2012;10(2):102-112.

27. Burton JH, Mitchell L, Thamm DH, et al. Low-dose cyclophosphamide selectively decreases regulatory T cells and inhibits angiogenesis in dogs with soft tissue sarcoma. J Vet Intern Med 2011;25(4):920-926.

28. Marchetti V, Giorgi M, Fioravanti A, et al. First-line metronomic chemotherapy in a metastatic model of spontaneous canine tumours: a pilot study. Invest New Drugs 2012;30(4):1725-1730.

29. Grosenbaugh DA, Leard AT, Bergman PJ, et al. Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. Am J Vet Res 2011;72(12):1631-1638.

30. USDA licenses DNA vaccine for treatment of melanoma in dogs. J Am Vet Med Assoc 2010;236(5):495.

31. Proulx DR, Ruslander DM, Dodge RK, et al. A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation. Vet Radiol Ultrasound 2003:44(3):352-359.

32. Murphy S, Hayes AM, Blackwood L, et al. Oral malignant melanoma—the effect of coarse fractionation radiotherapy alone or with adjuvant carboplatin therapy. Vet Comp Oncol 2005:3(4):222-229.

33. Freeman KP, Hahn KA, Harris FD, et al. Treatment of dogs with oral melanoma by hypofractionated radiation therapy and platinum-based chemotherapy (1987-1997). J Vet Intern Med 2003;17(1):96-101.

34. Overgaard J, Overgaard M, Hansen PV, et al. Some factors of importance in the radiation treatment of malignant melanoma. Radiother Oncol 1986;5(3):183-192.

35. Overgaard J. The role of radiotherapy in recurrent and metastatic malignant melanoma: a clinical radiobiological study. Int J Radiat Oncol Biol Phys 1986;12(6):867-872.


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