Ophthalmology Challenge: A greyhound with red eyes
Apr 01, 2005
A 4-year-old spayed female greyhound was presented to Colorado State University Veterinary Teaching Hospital for evaluation of redness in both eyes, a possible corneal ulcer in the right eye, and a scratch in the skin of the medial canthus of the left eye. The owner reported that a recent fight had caused the ocular and periocular lesions. The dog was a retired racing greyhound and had been with its current owners for two years. No other health-related complaints were noted.
Physical and ocular examinations
Differential diagnoses for the dog's ocular problems included chronic superficial keratitis, granulation tissue secondary to irritation or foreign bodies, neoplasia, and metabolic infiltrates (e.g. lipids, minerals). Keratoconjunctivitis sicca is another differential diagnosis in dogs presenting with these clinical signs, but it was ruled out because of the normal Schirmer tear test results. By carefully inspecting the conjunctiva and conjunctival fornices and evaluating the dog's ability to blink and completely close its eyelids over the corneas we were able to rule out exposure keratopathy or foreign bodies. The results of a complete blood count and serum chemistry profile were normal, indicating that neither hypercholesterolemia nor hypertriglyceridemia led to corneal lipid or cholesterol deposition. After applying a topical anesthetic to both eyes, we obtained a scraping of the tissue in each eye with a Kimura spatula and submitted the material for cytologic evaluation. The results showed numerous normal epithelial cells, lymphocytes, neutrophils, and occasional mast cells.
Diagnosis and treatment
The cytologic evaluation results combined with the other findings led to a diagnosis of chronic superficial keratitis (CSK). We prescribed prednisolone acetate 1% ophthalmic drops three times a day in both eyes for an indefinite period. In addition, we augmented the corticosteroid therapy by administering 0.2% cyclosporine ophthalmic ointment (Optimmune—Schering Plough Animal Health) twice a day in both eyes.